Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic marker of mortality in healthy, general and patient populations: protocol for a systematic review and meta-analysis

Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic marker of mortality in healthy, general and patient populations: protocol for a systematic review and meta-analysis

Introduction: Chronic inflammation is increasingly recognized as a major contributor to disease, disability and eventually death, but measure the degree of chronic inflammation remains non-saints, making it difficult to relate to chronic inflammation and death. Soluble urokinase plasminogen activator receptor (Supar), an emerging biomarker of chronic inflammation, has been proposed as a prognostic biomarker associated with the future occurrence of chronic diseases and mortality in general and patient populations.

precise prognostic biomarkers are important because they can help improve risk stratification in clinical settings and provide guidance in the treatment or lifestyle decisions as well as in the design of randomized trials. Here, we would like to summarize the evidence on the overall relationship of biomarker Supar death in the healthy population, the public and patients throughout the disease.


Methods and analysis: The search will be performed using Medline, Embase and Scopus databases from their inception to June 3, 2020 to identify studies investigating the ‘Supar’ and ‘death’. Observational studies and a control group of the study interventions were written in English or Danish will be included. Tools ‘Quality At Prognosis Studies’ will be used to assess the risk of bias of included studies. measures unadjusted and adjusted mortality outcomes (eg, risk ratio, OR, HR) with 95% CI are extracted to a healthy individual, general and patient populations. The primary outcome was all-cause mortality in any given follow-up. subgroup analysis will be based on the time of the results, the cause of death, type of population, adjusting for conventional risk factors and markers of inflammation.


Ethics and deployment: This systematic review will synthesize evidence on Supar use as a prognostic marker for mortality. The results will be disseminated by publications in peer-reviewed journals. Data used will be obtained from published studies, and therefore ethics approval is not required for this systematic review.

Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic marker of mortality in healthy, general and patient populations: protocol for a systematic review and meta-analysis
Soluble urokinase plasminogen activator receptor (suPAR) as a prognostic marker of mortality in healthy, general and patient populations: protocol for a systematic review and meta-analysis

Helicobacter pylori colonization Drives Urokinase Receptor (Upar) The expression in murine gastric epithelium During the Early Pathogenesis

Background: Persistent infection with Helicobacter pylori is the most important risk factor for gastric cancer. The urokinase receptor (Upar) upregulated in lesions and inflammation keep cancer invasion. evidence of H. pylori colonization tends to be correlated with increased expression of Upar in human gastric epithelium, but the link has not been established proximate cause in vivo; (2) Method: In a mouse model of H. pylori-induced gastritis, we investigate the emergence of Upar temporal protein expression in gastric mucosa in response to H. pylori (SS1 strain) infection; (3)

Results: We observed intense Upar foveolar immunoreactivity in the epithelial cells of the corpus of the stomach due to de novo synthesis, compared with non-infected animals. Upar induction is a response to the very beginning, but increased progressively over time as do the infiltration of immune cells. Eradication of H. pylori infections with antimicrobial therapy causes regression Upar expression to basic physiological level.

Rat Plasminogen Activator, Urokinase (uPA) ELISA Kit

RD-uPA-Ra-48Tests 48 Tests
EUR 511

Rat Plasminogen Activator, Urokinase (uPA) ELISA Kit

RD-uPA-Ra-96Tests 96 Tests
EUR 709

Bovine Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-b-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma or other biological fluids.

Bovine Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-b-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Bovine Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma or other biological fluids.

Human Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-Hu-48T 48T
EUR 441
Description: A sandwich quantitative ELISA assay kit for detection of Human Plasminogen Activator, Urokinase (uPA) in samples from plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-Hu-96T 96T
EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Human Plasminogen Activator, Urokinase (uPA) in samples from plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-Mu-48T 48T
EUR 489
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma or other biological fluids.

Mouse Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-Mu-96T 96T
EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma or other biological fluids.

Porcine Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-p-48T 48T
EUR 547
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma or other biological fluids.

Porcine Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-p-96T 96T
EUR 715
Description: A sandwich quantitative ELISA assay kit for detection of Porcine Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma or other biological fluids.

Rat Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Plasminogen Activator, Urokinase (uPA) ELISA Kit

DLR-uPA-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Plasminogen Activator, Urokinase (uPA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Bovine Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-b-48Tests 48 Tests
EUR 580

Bovine Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-b-96Tests 96 Tests
EUR 807

Human Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-Hu-48Tests 48 Tests
EUR 455

Human Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-Hu-96Tests 96 Tests
EUR 629

Mouse Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-Mu-48Tests 48 Tests
EUR 511

Mouse Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-Mu-96Tests 96 Tests
EUR 709

Porcine Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-p-48Tests 48 Tests
EUR 580

Porcine Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-p-96Tests 96 Tests
EUR 807

Rat Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-Ra-48Tests 48 Tests
EUR 534

Rat Plasminogen Activator, Urokinase (uPA) ELISA Kit

RDR-uPA-Ra-96Tests 96 Tests
EUR 742

uPA Enzyme

20-abx073030
  • EUR 230.00
  • EUR 300.00
  • EUR 773.00
  • 100 ug
  • 1 mg
  • 5 mg

uPA antibody

10-1945 200 ul
EUR 543
Description: Mouse monoclonal uPA antibody

uPA antibody

10-1946 200 ul
EUR 543
Description: Mouse monoclonal uPA antibody

uPA antibody

10-1947 200 ul
EUR 543
Description: Mouse monoclonal uPA antibody

uPA antibody

10-1948 200 ul
EUR 543
Description: Mouse monoclonal uPA antibody

uPA Polyclonal Antibody

ES6602-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against uPA from Human. This antibody is tested and validated for IHC, WB, ELISA

uPA Polyclonal Antibody

ES6602-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against uPA from Human. This antibody is tested and validated for IHC, WB, ELISA

uPA Polyclonal Antibody

ABP55603-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of uPA from Human. This uPA antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human uPA

uPA Polyclonal Antibody

ABP55603-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of uPA from Human. This uPA antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human uPA

uPA Polyclonal Antibody

ABP55603-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of uPA from Human. This uPA antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human uPA

Anti-uPA antibody

STJ96188 200 µl
EUR 197
Description: Rabbit polyclonal to uPA.

anti- uPA antibody

FNab09267 100µg
EUR 505.25
Description: Antibody raised against uPA

Anti-uPA antibody

PAab09267 100 ug
EUR 355

uPA Recombinant Protein

91-360 0.05 mg
EUR 710.75
Description: Recombinant Human Urokinase-Type Plasminogen Activator is a serine protease, which specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Human Urokinase-Type Plasminogen Activator is initially synthesized as 431 amino acid precursor with a N-terminal signal peptide residues. The single chain molecule is processed into a disulfide-linked two-chain molecule. There exists two forms A chain, the long A chain contains an EGF-like domain that is responsible for binding of the uPA receptor. The B chain corresponds to the catalytic domain.

Sheep UPA ELISA Kit

ESU0019 96Tests
EUR 521

Rabbit UPA ELISA Kit

ERTU0019 96Tests
EUR 521

Rat UPA ELISA Kit

ERU0019 96Tests
EUR 521

Monkey UPA ELISA Kit

EMKU0019 96Tests
EUR 521

Mouse UPA ELISA Kit

EMU0019 96Tests
EUR 521

Porcine UPA ELISA Kit

EPU0019 96Tests
EUR 521

Goat UPA ELISA Kit

EGTU0019 96Tests
EUR 521

Human UPA ELISA Kit

EHU0019 96Tests
EUR 521

Bovine UPA ELISA Kit

EBU0019 96Tests
EUR 521

Chicken UPA ELISA Kit

ECKU0019 96Tests
EUR 521

Canine UPA ELISA Kit

ECU0019 96Tests
EUR 521

Anserini UPA ELISA Kit

EAU0019 96Tests
EUR 521

Human Urokinase (uPA) Antibody

11651-05011 150 ug
EUR 217

Rat Urokinase (uPA) Antibody

12172-05011 150 ug
EUR 217

Human uPA ELISA kit

LF-EK50397 1×96T
EUR 648

PLAU / uPA Recombinant Protein

11-306 0.05 mg
EUR 595.25
Description: Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).

Human uPA ELISA Kit

55R-1696 1 kit
EUR 577
Description: ELISA kit for detection of uPA in the research laboratory

Recombinant Plasminogen Activator, Urokinase (uPA)

4-RPA140Mu01
  • EUR 504.99
  • EUR 238.00
  • EUR 1618.72
  • EUR 606.24
  • EUR 1112.48
  • EUR 401.00
  • EUR 3896.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Plasminogen Activator, Urokinase expressed in: E.coli

Recombinant Plasminogen Activator, Urokinase (uPA)

4-RPA140Po01
  • EUR 565.92
  • EUR 254.00
  • EUR 1847.20
  • EUR 682.40
  • EUR 1264.80
  • EUR 442.00
  • EUR 4468.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Pig Plasminogen Activator, Urokinase expressed in: E.coli

Recombinant Plasminogen Activator, Urokinase (uPA)

4-RPA140Ra01
  • EUR 526.50
  • EUR 244.00
  • EUR 1699.36
  • EUR 633.12
  • EUR 1166.24
  • EUR 415.00
  • EUR 4098.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Plasminogen Activator, Urokinase expressed in: E.coli

Anti-uPA Receptor/PLAUR Antibody

PA1344 100ug/vial
EUR 334

Guinea Pig UPA ELISA Kit

EGU0019 96Tests
EUR 521

Anti-uPA Receptor/PLAUR Antibody

A00993-1 100ug/vial
EUR 294

Anti-uPA Receptor/Plaur Antibody

A00993-2 100ug/vial
EUR 294

Anti-uPA Receptor/PLAUR Antibody

A00993-3 100ug/vial
EUR 334

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx129610
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx130234
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx110339
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx103303
  • EUR 453.00
  • EUR 133.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Plasminogen Activator, Urokinase (uPA) Antibody

abx022855-1mg 1 mg
EUR 1066

Plasminogen Activator, Urokinase (uPA) Antibody

abx022856-02mg 0.2 mg
EUR 495

Plasminogen Activator, Urokinase (uPA) Antibody

abx033923-400ul 400 ul
EUR 523

Plasminogen Activator, Urokinase (uPA) Antibody

abx033923-80l 80 µl
EUR 286

Plasminogen Activator, Urokinase (uPA) Antibody

abx239267-100ug 100 ug
EUR 481

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx178032
  • EUR 996.00
  • EUR 495.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx178033
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx178034
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx178036
  • EUR 1288.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx174088
  • EUR 718.00
  • EUR 384.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx174089
  • EUR 843.00
  • EUR 439.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx174090
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

Plasminogen Activator, Urokinase (uPA) Antibody

20-abx174091
  • EUR 913.00
  • EUR 467.00
  • 1 mg
  • 200 ug

UPA ELISA Kit (Cattle) (OKCD04432)

OKCD04432 96 Wells
EUR 936
Description: Description of target: ;Species reactivity: Cattle;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.061 ng/mL

uPA ELISA Kit (Human) (OKBB00267)

OKBB00267 96 Tests
EUR 505
Description: Description of target: Plasminogen activator,urokinase (PLAU, uPA) converts plasminogen to plasmin. Plasmin is involved in processing of amyloid precursor protein and degrades secreted and aggregated amyloid-beta, a hallmark of Alzheimer disease (AD). Urokinase has a molecular mass of about 54 kD and is composed of 2 disulfide-linked chains, A and B, of molecular masses 18 kD and 33 kD, respectively. It localized on 10q24. uPA facilitates cell migration by localizing proteolisys on the cell surface and by inducing intracellular signalling pathways. In human vascular smooth muscle cell (VSMC), uPA stimulates migration via the uPA receptor (uPAR) signalling complex containing TYK2 and phosphatidylinositol 3-kinase (PI3-K).;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 5 pg/mL

PLAU/uPA ELISA KIT|Human

EF000376 96 Tests
EUR 689

Human uPA ELISA kit (4X96T)

LF-EK50398 4×96T
EUR 2201

Human CellExp? UPA, human recombinant

7248-10
EUR 332

Human CellExp? UPA, human recombinant

7248-50
EUR 1104

Human uPA/PLAU PicoKine ELISA Kit

EK0535 96 wells
EUR 426
Description: For quantitative detection of human uPA in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human Urokinase (uPA) Antibody (Biotin Conjugate)

11651-05021 150 ug
EUR 276

Rat Urokinase (uPA) Antibody (Biotin Conjugate)

12172-05021 150 ug
EUR 276

Human Urokinase (uPA) AssayMax ELISA Kit

EU1001-1 96 Well Plate
EUR 417

Plasminogen Activator, Urokinase (uPA) Antibody (Biotin)

20-abx106060
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Plasminogen Activator, Urokinase (uPA) Antibody (FITC)

20-abx107474
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Plasminogen Activator, Urokinase (uPA) Antibody (HRP)

20-abx108893
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Plasminogen Activator, Urokinase (uPA) Protein

20-abx654747
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Suppression of the inflammatory response by prostaglandin E2 expression Upar debilitating treatment. Despite this relationship, H. pylori does not induce the expression of Upar in vitro in cells co-cultured with gastric cancer; (4) Conclusion: We showed that persistent H. pylori colonization is an important event for the emergence of a relatively high Upar protein expression in murine gastric epithelial cells.

Dustin

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