poison ligand-targeted (LTTs) are artificial molecules that consist of a targeting component associated with the toxins that induce cell death after binding targets LTT. targeting bispecific allows for the simultaneous targeting of two receptors. In this review, we mostly focus on epidermal growth factor receptor (EGFR) as a target. We discuss the development and testing of LTT bispecific targeting EGFR and urokinase-type plasminogen activator receptor (Upar) as two attractive targets involved in tumor growth and in the regulation of the tumor microvasculature in solid tumors. In vitro and mouse xenograft studies have demonstrated that EGFR-targeted bispecific angiotoxin (eBAT) effective against human solid tumors. Studies have shown that eBAT dog is safe and effective against canine hemangiosarcoma, which are physiologically similar to human angiosarcoma.

Finding the right dose strategy and sequencing eBAT administration, in combination with other therapies, among the factors important for the future direction. Together, the data suggest that stem cells eBAT cancer targets, may have a role in inhibiting tumor blood vessels, human, and bispecific conformations that may have a role in reducing the toxicity of the oncologic comparative trials in dogs.
The urokinase plasminogen activator and its receptor (uPA / Upar) is a biomarker for metastasis, particularly in triple-negative breast cancer.

We set up an anti-mitotic N-alkylisatin (N-AI) -loaded liposomes functionalized with uPA / Upar targeting ligand, plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2), and rated liposome uptake in vitro and in vivo. receptor dependent uptake of liposome-functionalized PAI-2 was significantly higher in the uPA / Upar overexpressing MDA-MB-231 breast cancer cells is relatively low Upar / Upar expressing MCF-7 breast cancer cells. Furthermore, N-AI cytotoxicity enhanced by receptor-dependent manner.

In vivo, PAI-2 N-AI liposomes have a plasma half-life of 5.82 h and showed increased accumulation at the primary tumor site in the MDA-MB-231 BALB / c-Fox1nu / Ausb mouse orthotopic xenograft model, relative to non-functionalized liposome , up to 6 hours post injection. These findings support the further development of the N-AI-loaded liposomes PAI-2-enabled for breast cancer uPA / Upar-positive, especially against triple-negative breast cancer, the prognosis is poor and treatment is limited.

Soluble urokinase plasminogen activator receptor as a prognostic biomarker for long-term acute coronary syndrome

Objective: The aim of our study was to analyze the long-term prognostic value soluble urokinase plasminogen activator receptor (Supar) in the setting of acute coronary syndromes (ACS) .Methods: We included 340 patients with ACS undergoing coronary angiography and plasma concentrations were measured Supar. Patients were classified into Supar low concentrations (<2.6 ng / mL) and high Supar concentration (≥2.6 ng / mL) and long-term events are evaluated.

Supar rated prognostic value beyond the clinical model that included age, GRACE score, estimated glomerular filtration rate, cardiac troponin-I peak and left ventricular ejection fraction <40% .Results: Higher concentrations Supar associated with an increased prevalence of cardiovascular risk factors.

Human Urokinase
7-03802	CHI Scientific	100µg	Ask for price

Human Urokinase
7-03803	CHI Scientific	1mg	Ask for price

Human Urokinase
7-03804	CHI Scientific	5mg	Ask for price

Human Urokinase
RP-1463	Alpha Diagnostics	100 ug	EUR 196.8

MG 1
HY-U00110	MedChemExpress	5mg	EUR 721.2

Human Genomic DNA
X11000	EpiGentek	Ask for price EUR 235.40	0.2 ml 0.2 ml

Human Brain Genomic DNA
X11001	EpiGentek	Ask for price EUR 77.00	10 µg 10 ul

Monoolien-9 (100 mg)
MLCP-RMO9-1	MiTeGen	100 mg	EUR 95
Description: Monoolien-9 (100 mg)

Urokinase
30R-2710	Fitzgerald	100 ug	EUR 507.6
Description: Purified native Human Urokinase

Urokinase
4793-100	Biovision		EUR 385.2

Urokinase,
4793-1000	Biovision		EUR 1618.8

Urokinase, human recombinant
7696-10	Biovision		EUR 261.6

Urokinase, human recombinant
7696-50	Biovision		EUR 652.8

Urokinase, human recombinant
7696-500	Biovision		EUR 2271.6

rRTF (1-mg)*
41055-2	Pel-Freez	1mg	EUR 1009.78

Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody
11661-05011	AssayPro	150 ug	EUR 260.4

Custom Peptide Conjugation to KLH/BSA/Ovalbumin or agarose (mg-100 mg size, price based upon servicesa)
CONJ-1	Alpha Diagnostics	1	Ask for price

Synthetic Adjuvant Combo Pak-1 (contains 1 mg of Gardiquimod (#AV-8010), Imiquimod (#AV-8015) and 1 mg R848 (#AV-8020-1)
AV-8000-PK-1	Alpha Diagnostics	1 pk	EUR 416.4

Accuris 1 Hour Mammalian Genotyping Kit
PR1300-MG-400	Benchmark Scientific	1 PC	EUR 544.06

Accuris 1 Hour Mammalian Genotyping Kit
PR1300-MG-80	Benchmark Scientific	1 PC	EUR 185.18

Accuris 1 Hour Mammalian Genotyping Kit
PR1300-MG-S	Benchmark Scientific	1 PC	EUR 85.66

Urokinase antibody
5793-100	Biovision		EUR 405.6

Urokinase antibody
5793-30T	Biovision		EUR 175.2

Urokinase protein
30C-CP8107	Fitzgerald	50 ug	EUR 486
Description: Purified Recombinant Human Urokinase protein

Urokinase Antibody
49439-100ul	SAB	100ul	EUR 399.6

Urokinase Antibody
49439-50ul	SAB	50ul	EUR 286.8

Urokinase Antibody
abx024172-200ul	Abbexa	200 ul	EUR 693.6

Urokinase Antibody
F51093-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

Urokinase Antibody
F52084-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag
E80025	EpiGentek	EUR 635.80 EUR 3934.70	100 ul 1 ml

Human Urokinase (uPA) Antibody
11651-05011	AssayPro	150 ug	EUR 260.4

Pro-Urokinase, human recombinant
7695-10	Biovision		EUR 242.4

Pro-Urokinase, human recombinant
7695-50	Biovision		EUR 574.8

Pro-Urokinase, human recombinant
7695-500	Biovision		EUR 2010

Human Urokinase ELISA kit
E01U0010-192T	BlueGene	192 tests	EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit
E01U0010-48	BlueGene	1 plate of 48 wells	EUR 624
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit
E01U0010-96	BlueGene	1 plate of 96 wells	EUR 822
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase-type plasminogen activator (PLAU)
1-CSB-RP143194h(A4)	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Urokinase-type plasminogen activator(PLAU),partial expressed in E.coli

CF405S monoclonal mouse anti-biotin IgG, 2 mg/mL
20203-1	Biotium	50uL	EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF488A monoclonal mouse anti-biotin IgG, 2 mg/mL
20204-1	Biotium	50uL	EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF594 monoclonal mouse anti-biotin IgG, 2 mg/mL
20205-1	Biotium	50uL	EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF633 monoclonal mouse anti-biotin IgG, 2 mg/mL
20206-1	Biotium	50uL	EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF640R monoclonal mouse anti-biotin IgG, 2 mg/mL
20207-1	Biotium	50uL	EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

Histone H3 Methylation Antibody Panel Pack I – Active Genes
C10000	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack I – Repression Genes
C10001	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack II – Active Genes
C10002	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3 Methylation Antibody Panel Pack II – Repression Genes
C10003	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack III – Active Genes
C10004	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3K4 Methylation Antibody Panel Pack
C10005	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K9 Methylation Antibody Panel Pack
C10006	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K27 Methylation Antibody Panel Pack
C10007	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K36 Methylation Antibody Panel Pack
C10008	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3K79 Methylation Antibody Panel Pack
C10009	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3 Acetylation Antibody Panel Pack I
C10010	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H3 Acetylation Antibody Panel Pack II
C10011	EpiGentek	EUR 928.26 EUR 588.50	4 x 25 µg 4 x 25 ul

Histone H4K20 Methylation Antibody Panel Pack
C10012	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H4 Acetylation Antibody Panel Pack
C10013	EpiGentek	EUR 754.26 EUR 470.80	4 x 25 µg 4 x 25 ul

Histone H3 Phosphorylation Antibody Panel Pack
C10014	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R2 Methylation Antibody Panel Pack
C10015	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R8 Methylation Antibody Panel Pack
C10016	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R17 Methylation Antibody Panel Pack
C10017	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H3R26 Methylation Antibody Panel Pack
C10018	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

Histone H4R3 Methylation Antibody Panel Pack
C10019	EpiGentek	EUR 754.26 EUR 470.80	3 x 25 µg 3 x 25 ul

DNA Methylation Antibody Panel Pack I
C20000	EpiGentek	EUR 458.46 EUR 270.60	2 x 25 ul

DNMT3A Protein
E11000	EpiGentek	EUR 971.76 EUR 618.20	10 µg 10 ul

TET1 Protein (Active)
E12002	EpiGentek	EUR 387.12 EUR 225.50	10 µg 10 ul

DNMT3B Protein
E14000	EpiGentek	EUR 971.76 EUR 618.20	10 µg 10 ul

DNMT1 Protein
E15000	EpiGentek	EUR 971.76 EUR 618.20	10 µg 10 ul

HDAC1 Protein
E24002	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC10 Protein
E24003	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC11 Protein
E24004	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC2 Protein
E24005	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC3 Protein
E24006	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC4 Protein
E24007	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

HDAC5 Protein
E24008	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

HDAC6 Protein
E24009	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC7 Protein
E24010	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

HDAC8 Protein
E24011	EpiGentek	EUR 968.28 EUR 616.00	50 µg 50 ul

HDAC9 Protein
E24012	EpiGentek	EUR 968.28 EUR 616.00	10 µg 10 ul

H3F3A Protein
E35003	EpiGentek	EUR 174.84 EUR 78.10	50 µg 50 ul

H4 Protein
E35005	EpiGentek	EUR 174.84 EUR 78.10	50 µg 50 ul

SOD1 Protein
E70000	EpiGentek	EUR 599.40 EUR 365.20	25 µg 25 ul

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated
A12001	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

Goat Anti-Rat Secondary Antibody, Biotin Conjugated
A12002	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

HRP-Goat Anti-Mouse Secondary Antibody
A12003	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

HRP-Goat Anti-Rabbit Secondary Antibody
A12004	EpiGentek	EUR 232.26 EUR 117.70	350 µg 350 ug

EpiMag HT (96-Well) Magnetic Separator
Q10002	EpiGentek	EUR 416.70 EUR 258.50	1/Pack 1/Pack

EpiMag 96-Well Microplate (5/pack)
Q10003	EpiGentek	EUR 136.56 EUR 52.80	5/pack 5/pack

Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size)
20007-1-BL-1	Alpha Diagnostics	10 ml	Ask for price

Human ?1-microglobulin,?1-MG ELISA Kit
201-12-1093	SunredBio	96 tests	EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

CF633 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20132-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20154-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF555 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20230-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF647 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20280-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF488A goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20022-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF488A Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20071-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF594 Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20072-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF488A Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20074-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF594 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20075-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF633 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20076-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF640R goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20081-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20097-1	Biotium	50uL	EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

Pepsin, 1 mg, lyophilized
6011	Chondrex	1 mg	EUR 75.66
Description: Pepsin

Cyanine3 maleimide, 1 mg
11080	Lumiprobe	1 mg	EUR 129.6

Cyanine3 amine, 1 mg
110C0	Lumiprobe	1 mg	EUR 129.6

Pyrene hydrazide, 1 mg
13570	Lumiprobe	1 mg	EUR 129.6

Pyrene maleimide, 1 mg
13580	Lumiprobe	1 mg	EUR 129.6

Cyanine5 hydrazide, 1 mg
13070	Lumiprobe	1 mg	EUR 129.6

Cyanine5 maleimide, 1 mg
13080	Lumiprobe	1 mg	EUR 129.6

Cyanine5 amine, 1 mg
130C0	Lumiprobe	1 mg	EUR 129.6

Cyanine3 azide, 1 mg
A1030	Lumiprobe	1 mg	EUR 129.6

Cyanine3 alkyne, 1 mg
A10B0	Lumiprobe	1 mg	EUR 129.6

Cyanine3 DBCO, 1 mg
A10F0	Lumiprobe	1 mg	EUR 129.6

Cyanine5.5 amine, 1 mg
170C0	Lumiprobe	1 mg	EUR 129.6

Cyanine7 hydrazide, 1 mg
15070	Lumiprobe	1 mg	EUR 129.6

Cyanine7 maleimide, 1 mg
15080	Lumiprobe	1 mg	EUR 129.6

Cyanine7 amine, 1 mg
150C0	Lumiprobe	1 mg	EUR 129.6

Cyanine7.5 maleimide, 1 mg
16080	Lumiprobe	1 mg	EUR 129.6

Cyanine7.5 amine, 1 mg
160C0	Lumiprobe	1 mg	EUR 129.6

Cyanine5 azide, 1 mg
A3030	Lumiprobe	1 mg	EUR 129.6

Cyanine5 alkyne, 1 mg
A30B0	Lumiprobe	1 mg	EUR 129.6

Cyanine5 DBCO, 1 mg
A30F0	Lumiprobe	1 mg	EUR 129.6

Cyanine5.5 azide, 1 mg
A4030	Lumiprobe	1 mg	EUR 129.6

PEP azide, 1 mg
A4530	Lumiprobe	1 mg	EUR 129.6

Cyanine5.5 alkyne, 1 mg
A70B0	Lumiprobe	1 mg	EUR 129.6

Cyanine5.5 DBCO, 1 mg
A70F0	Lumiprobe	1 mg	EUR 129.6

Cyanine7 alkyne, 1 mg
A50B0	Lumiprobe	1 mg	EUR 129.6

Cyanine7 DBCO, 1 mg
A50F0	Lumiprobe	1 mg	EUR 129.6

Cyanine7.5 azide, 1 mg
A6030	Lumiprobe	1 mg	EUR 129.6

Cyanine7.5 alkyne, 1 mg
A60B0	Lumiprobe	1 mg	EUR 129.6

Cyanine3.5 azide, 1 mg
A2030	Lumiprobe	1 mg	EUR 129.6

After multivariate adjustment, Supar ≥2.6 ng / mL were independently associated with an increased risk of all-cause mortality (HR 2.3; 95% CI 1.2 to 4.4; p = 0.017), major adverse cardiovascular events (MACE) ( HR 1.7; 95% CI 1.1 to 2.5; p = 0.020) and heart failure (HR 4.1; 95% CI 1.3 to 12.6; p = 0.015), but not with myocardial infarction , For long-term all-cause mortality significant increase of reclassification and discrimination Supar look after addition to the clinical model.