
N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer
poison ligand-targeted (LTTs) are artificial molecules that consist of a targeting component associated with the toxins that induce cell death after binding targets LTT. targeting bispecific allows for the simultaneous targeting of two receptors. In this review, we mostly focus on epidermal growth factor receptor (EGFR) as a target. We discuss the development and testing of LTT bispecific targeting EGFR and urokinase-type plasminogen activator receptor (Upar) as two attractive targets involved in tumor growth and in the regulation of the tumor microvasculature in solid tumors. In vitro and mouse xenograft studies have demonstrated that EGFR-targeted bispecific angiotoxin (eBAT) effective against human solid tumors. Studies have shown that eBAT dog is safe and effective against canine hemangiosarcoma, which are physiologically similar to human angiosarcoma.
Finding the right dose strategy and sequencing eBAT administration, in combination with other therapies, among the factors important for the future direction. Together, the data suggest that stem cells eBAT cancer targets, may have a role in inhibiting tumor blood vessels, human, and bispecific conformations that may have a role in reducing the toxicity of the oncologic comparative trials in dogs.
The urokinase plasminogen activator and its receptor (uPA / Upar) is a biomarker for metastasis, particularly in triple-negative breast cancer.
We set up an anti-mitotic N-alkylisatin (N-AI) -loaded liposomes functionalized with uPA / Upar targeting ligand, plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2), and rated liposome uptake in vitro and in vivo. receptor dependent uptake of liposome-functionalized PAI-2 was significantly higher in the uPA / Upar overexpressing MDA-MB-231 breast cancer cells is relatively low Upar / Upar expressing MCF-7 breast cancer cells. Furthermore, N-AI cytotoxicity enhanced by receptor-dependent manner.
In vivo, PAI-2 N-AI liposomes have a plasma half-life of 5.82 h and showed increased accumulation at the primary tumor site in the MDA-MB-231 BALB / c-Fox1nu / Ausb mouse orthotopic xenograft model, relative to non-functionalized liposome , up to 6 hours post injection. These findings support the further development of the N-AI-loaded liposomes PAI-2-enabled for breast cancer uPA / Upar-positive, especially against triple-negative breast cancer, the prognosis is poor and treatment is limited.

Soluble urokinase plasminogen activator receptor as a prognostic biomarker for long-term acute coronary syndrome
Objective: The aim of our study was to analyze the long-term prognostic value soluble urokinase plasminogen activator receptor (Supar) in the setting of acute coronary syndromes (ACS) .Methods: We included 340 patients with ACS undergoing coronary angiography and plasma concentrations were measured Supar. Patients were classified into Supar low concentrations (<2.6 ng / mL) and high Supar concentration (≥2.6 ng / mL) and long-term events are evaluated.
Supar rated prognostic value beyond the clinical model that included age, GRACE score, estimated glomerular filtration rate, cardiac troponin-I peak and left ventricular ejection fraction <40% .Results: Higher concentrations Supar associated with an increased prevalence of cardiovascular risk factors.
Human Urokinase |
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7-03802 | CHI Scientific | 100µg | Ask for price |
Human Urokinase |
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7-03803 | CHI Scientific | 1mg | Ask for price |
Human Urokinase |
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7-03804 | CHI Scientific | 5mg | Ask for price |
Human Urokinase |
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RP-1463 | Alpha Diagnostics | 100 ug | EUR 196.8 |
MG 1 |
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HY-U00110 | MedChemExpress | 5mg | EUR 721.2 |
Human Genomic DNA |
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X11000 | EpiGentek |
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Human Brain Genomic DNA |
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X11001 | EpiGentek |
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Monoolien-9 (100 mg) |
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MLCP-RMO9-1 | MiTeGen | 100 mg | EUR 95 |
Description: Monoolien-9 (100 mg) |
Urokinase |
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30R-2710 | Fitzgerald | 100 ug | EUR 507.6 |
Description: Purified native Human Urokinase |
Urokinase |
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4793-100 | Biovision | EUR 385.2 |
Urokinase, |
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4793-1000 | Biovision | EUR 1618.8 |
Urokinase, human recombinant |
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7696-10 | Biovision | EUR 261.6 |
Urokinase, human recombinant |
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7696-50 | Biovision | EUR 652.8 |
Urokinase, human recombinant |
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7696-500 | Biovision | EUR 2271.6 |
rRTF (1-mg)* |
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41055-2 | Pel-Freez | 1mg | EUR 1009.78 |
Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody |
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11661-05011 | AssayPro | 150 ug | EUR 260.4 |
Custom Peptide Conjugation to KLH/BSA/Ovalbumin or agarose (mg-100 mg size, price based upon servicesa) |
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CONJ-1 | Alpha Diagnostics | 1 | Ask for price |
Synthetic Adjuvant Combo Pak-1 (contains 1 mg of Gardiquimod (#AV-8010), Imiquimod (#AV-8015) and 1 mg R848 (#AV-8020-1) |
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AV-8000-PK-1 | Alpha Diagnostics | 1 pk | EUR 416.4 |
Accuris 1 Hour Mammalian Genotyping Kit |
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PR1300-MG-400 | Benchmark Scientific | 1 PC | EUR 544.06 |
Accuris 1 Hour Mammalian Genotyping Kit |
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PR1300-MG-80 | Benchmark Scientific | 1 PC | EUR 185.18 |
Accuris 1 Hour Mammalian Genotyping Kit |
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PR1300-MG-S | Benchmark Scientific | 1 PC | EUR 85.66 |
Urokinase antibody |
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5793-100 | Biovision | EUR 405.6 |
Urokinase antibody |
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5793-30T | Biovision | EUR 175.2 |
Urokinase protein |
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30C-CP8107 | Fitzgerald | 50 ug | EUR 486 |
Description: Purified Recombinant Human Urokinase protein |
Urokinase Antibody |
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49439-100ul | SAB | 100ul | EUR 399.6 |
Urokinase Antibody |
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49439-50ul | SAB | 50ul | EUR 286.8 |
Urokinase Antibody |
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abx024172-200ul | Abbexa | 200 ul | EUR 693.6 |
Urokinase Antibody |
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F51093-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
Urokinase Antibody |
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F52084-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag |
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E80025 | EpiGentek |
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Human Urokinase (uPA) Antibody |
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11651-05011 | AssayPro | 150 ug | EUR 260.4 |
Pro-Urokinase, human recombinant |
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7695-10 | Biovision | EUR 242.4 |
Pro-Urokinase, human recombinant |
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7695-50 | Biovision | EUR 574.8 |
Pro-Urokinase, human recombinant |
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7695-500 | Biovision | EUR 2010 |
Human Urokinase ELISA kit |
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E01U0010-192T | BlueGene | 192 tests | EUR 1524 |
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Urokinase ELISA kit |
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E01U0010-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Urokinase ELISA kit |
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E01U0010-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human Urokinase-type plasminogen activator (PLAU) |
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1-CSB-RP143194h(A4) | Cusabio |
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Description: Recombinant Human Urokinase-type plasminogen activator(PLAU),partial expressed in E.coli |
CF405S monoclonal mouse anti-biotin IgG, 2 mg/mL |
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20203-1 | Biotium | 50uL | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 50uL |
CF488A monoclonal mouse anti-biotin IgG, 2 mg/mL |
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20204-1 | Biotium | 50uL | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 50uL |
CF594 monoclonal mouse anti-biotin IgG, 2 mg/mL |
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20205-1 | Biotium | 50uL | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 50uL |
CF633 monoclonal mouse anti-biotin IgG, 2 mg/mL |
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20206-1 | Biotium | 50uL | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 50uL |
CF640R monoclonal mouse anti-biotin IgG, 2 mg/mL |
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20207-1 | Biotium | 50uL | EUR 178.8 |
Description: Minimum order quantity: 1 unit of 50uL |
Histone H3 Methylation Antibody Panel Pack I – Active Genes |
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C10000 | EpiGentek |
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Histone H3 Methylation Antibody Panel Pack I – Repression Genes |
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C10001 | EpiGentek |
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Histone H3 Methylation Antibody Panel Pack II – Active Genes |
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C10002 | EpiGentek |
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Histone H3 Methylation Antibody Panel Pack II – Repression Genes |
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C10003 | EpiGentek |
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Histone H3 Methylation Antibody Panel Pack III – Active Genes |
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C10004 | EpiGentek |
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Histone H3K4 Methylation Antibody Panel Pack |
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C10005 | EpiGentek |
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Histone H3K9 Methylation Antibody Panel Pack |
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C10006 | EpiGentek |
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Histone H3K27 Methylation Antibody Panel Pack |
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C10007 | EpiGentek |
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Histone H3K36 Methylation Antibody Panel Pack |
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C10008 | EpiGentek |
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Histone H3K79 Methylation Antibody Panel Pack |
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C10009 | EpiGentek |
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Histone H3 Acetylation Antibody Panel Pack I |
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C10010 | EpiGentek |
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Histone H3 Acetylation Antibody Panel Pack II |
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C10011 | EpiGentek |
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Histone H4K20 Methylation Antibody Panel Pack |
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C10012 | EpiGentek |
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Histone H4 Acetylation Antibody Panel Pack |
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C10013 | EpiGentek |
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Histone H3 Phosphorylation Antibody Panel Pack |
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C10014 | EpiGentek |
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Histone H3R2 Methylation Antibody Panel Pack |
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C10015 | EpiGentek |
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Histone H3R8 Methylation Antibody Panel Pack |
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C10016 | EpiGentek |
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Histone H3R17 Methylation Antibody Panel Pack |
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C10017 | EpiGentek |
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Histone H3R26 Methylation Antibody Panel Pack |
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C10018 | EpiGentek |
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Histone H4R3 Methylation Antibody Panel Pack |
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C10019 | EpiGentek |
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DNA Methylation Antibody Panel Pack I |
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C20000 | EpiGentek |
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DNMT3A Protein |
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E11000 | EpiGentek |
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TET1 Protein (Active) |
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E12002 | EpiGentek |
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DNMT3B Protein |
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E14000 | EpiGentek |
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DNMT1 Protein |
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E15000 | EpiGentek |
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HDAC1 Protein |
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E24002 | EpiGentek |
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HDAC10 Protein |
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E24003 | EpiGentek |
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HDAC11 Protein |
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E24004 | EpiGentek |
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HDAC2 Protein |
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E24005 | EpiGentek |
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HDAC3 Protein |
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E24006 | EpiGentek |
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HDAC4 Protein |
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E24007 | EpiGentek |
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HDAC5 Protein |
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E24008 | EpiGentek |
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HDAC6 Protein |
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E24009 | EpiGentek |
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HDAC7 Protein |
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E24010 | EpiGentek |
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HDAC8 Protein |
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E24011 | EpiGentek |
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HDAC9 Protein |
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E24012 | EpiGentek |
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H3F3A Protein |
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E35003 | EpiGentek |
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H4 Protein |
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E35005 | EpiGentek |
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SOD1 Protein |
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E70000 | EpiGentek |
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Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated |
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A12001 | EpiGentek |
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Goat Anti-Rat Secondary Antibody, Biotin Conjugated |
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A12002 | EpiGentek |
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HRP-Goat Anti-Mouse Secondary Antibody |
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A12003 | EpiGentek |
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HRP-Goat Anti-Rabbit Secondary Antibody |
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A12004 | EpiGentek |
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EpiMag HT (96-Well) Magnetic Separator |
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Q10002 | EpiGentek |
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EpiMag 96-Well Microplate (5/pack) |
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Q10003 | EpiGentek |
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Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size) |
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20007-1-BL-1 | Alpha Diagnostics | 10 ml | Ask for price |
Human ?1-microglobulin,?1-MG ELISA Kit |
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201-12-1093 | SunredBio | 96 tests | EUR 528 |
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
CF633 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20132-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF594 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20154-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF555 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20230-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF647 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20280-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF488A goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20022-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF488A Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20071-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF594 Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20072-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF488A Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20074-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF594 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20075-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF633 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20076-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF640R goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20081-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
CF568 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL |
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20097-1 | Biotium | 50uL | EUR 164.4 |
Description: Minimum order quantity: 1 unit of 50uL |
Pepsin, 1 mg, lyophilized |
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6011 | Chondrex | 1 mg | EUR 75.66 |
Description: Pepsin |
Cyanine3 maleimide, 1 mg |
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11080 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine3 amine, 1 mg |
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110C0 | Lumiprobe | 1 mg | EUR 129.6 |
Pyrene hydrazide, 1 mg |
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13570 | Lumiprobe | 1 mg | EUR 129.6 |
Pyrene maleimide, 1 mg |
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13580 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5 hydrazide, 1 mg |
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13070 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5 maleimide, 1 mg |
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13080 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5 amine, 1 mg |
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130C0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine3 azide, 1 mg |
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A1030 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine3 alkyne, 1 mg |
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A10B0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine3 DBCO, 1 mg |
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A10F0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5.5 amine, 1 mg |
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170C0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7 hydrazide, 1 mg |
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15070 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7 maleimide, 1 mg |
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15080 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7 amine, 1 mg |
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150C0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7.5 maleimide, 1 mg |
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16080 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7.5 amine, 1 mg |
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160C0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5 azide, 1 mg |
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A3030 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5 alkyne, 1 mg |
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A30B0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5 DBCO, 1 mg |
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A30F0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5.5 azide, 1 mg |
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A4030 | Lumiprobe | 1 mg | EUR 129.6 |
PEP azide, 1 mg |
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A4530 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5.5 alkyne, 1 mg |
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A70B0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine5.5 DBCO, 1 mg |
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A70F0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7 alkyne, 1 mg |
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A50B0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7 DBCO, 1 mg |
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A50F0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7.5 azide, 1 mg |
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A6030 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine7.5 alkyne, 1 mg |
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A60B0 | Lumiprobe | 1 mg | EUR 129.6 |
Cyanine3.5 azide, 1 mg |
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A2030 | Lumiprobe | 1 mg | EUR 129.6 |
After multivariate adjustment, Supar ≥2.6 ng / mL were independently associated with an increased risk of all-cause mortality (HR 2.3; 95% CI 1.2 to 4.4; p = 0.017), major adverse cardiovascular events (MACE) ( HR 1.7; 95% CI 1.1 to 2.5; p = 0.020) and heart failure (HR 4.1; 95% CI 1.3 to 12.6; p = 0.015), but not with myocardial infarction , For long-term all-cause mortality significant increase of reclassification and discrimination Supar look after addition to the clinical model.
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