N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

poison ligand-targeted (LTTs) are artificial molecules that consist of a targeting component associated with the toxins that induce cell death after binding targets LTT. targeting bispecific allows for the simultaneous targeting of two receptors. In this review, we mostly focus on epidermal growth factor receptor (EGFR) as a target. We discuss the development and testing of LTT bispecific targeting EGFR and urokinase-type plasminogen activator receptor (Upar) as two attractive targets involved in tumor growth and in the regulation of the tumor microvasculature in solid tumors. In vitro and mouse xenograft studies have demonstrated that EGFR-targeted bispecific angiotoxin (eBAT) effective against human solid tumors. Studies have shown that eBAT dog is safe and effective against canine hemangiosarcoma, which are physiologically similar to human angiosarcoma.

Finding the right dose strategy and sequencing eBAT administration, in combination with other therapies, among the factors important for the future direction. Together, the data suggest that stem cells eBAT cancer targets, may have a role in inhibiting tumor blood vessels, human, and bispecific conformations that may have a role in reducing the toxicity of the oncologic comparative trials in dogs.
The urokinase plasminogen activator and its receptor (uPA / Upar) is a biomarker for metastasis, particularly in triple-negative breast cancer.

We set up an anti-mitotic N-alkylisatin (N-AI) -loaded liposomes functionalized with uPA / Upar targeting ligand, plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2), and rated liposome uptake in vitro and in vivo. receptor dependent uptake of liposome-functionalized PAI-2 was significantly higher in the uPA / Upar overexpressing MDA-MB-231 breast cancer cells is relatively low Upar / Upar expressing MCF-7 breast cancer cells. Furthermore, N-AI cytotoxicity enhanced by receptor-dependent manner.

In vivo, PAI-2 N-AI liposomes have a plasma half-life of 5.82 h and showed increased accumulation at the primary tumor site in the MDA-MB-231 BALB / c-Fox1nu / Ausb mouse orthotopic xenograft model, relative to non-functionalized liposome , up to 6 hours post injection. These findings support the further development of the N-AI-loaded liposomes PAI-2-enabled for breast cancer uPA / Upar-positive, especially against triple-negative breast cancer, the prognosis is poor and treatment is limited.

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer
N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

Soluble urokinase plasminogen activator receptor as a prognostic biomarker for long-term acute coronary syndrome

Objective: The aim of our study was to analyze the long-term prognostic value soluble urokinase plasminogen activator receptor (Supar) in the setting of acute coronary syndromes (ACS) .Methods: We included 340 patients with ACS undergoing coronary angiography and plasma concentrations were measured Supar. Patients were classified into Supar low concentrations (<2.6 ng / mL) and high Supar concentration (≥2.6 ng / mL) and long-term events are evaluated.

Supar rated prognostic value beyond the clinical model that included age, GRACE score, estimated glomerular filtration rate, cardiac troponin-I peak and left ventricular ejection fraction <40% .Results: Higher concentrations Supar associated with an increased prevalence of cardiovascular risk factors.

Human Urokinase (uPA) AssayMax ELISA Kit

EU1001-1 96 Well Plate
EUR 417

EZSolution? MG-115

2144-1
EUR 137

Camptothecin (2 mg/ml)

1039-1
EUR 142

Human Urokinase

7-03802 100µg Ask for price

Human Urokinase

7-03803 1mg Ask for price

Human Urokinase

7-03804 5mg Ask for price

Human Urokinase

RP-1463 100 ug
EUR 164

MG 1

HY-U00110 5mg
EUR 601

Urokinase

30R-2710 100 ug
EUR 423
Description: Purified native Human Urokinase

Urokinase

4793-100
EUR 321

Urokinase,

4793-1000
EUR 1349

Urokinase, human recombinant

7696-10
EUR 218

Urokinase, human recombinant

7696-50
EUR 544

Urokinase, human recombinant

7696-500
EUR 1893

Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody

11661-05011 150 ug
EUR 217

Synthetic Adjuvant Combo Pak-1 (contains 1 mg of Gardiquimod (#AV-8010), Imiquimod (#AV-8015) and 1 mg R848 (#AV-8020-1)

AV-8000-PK-1 1 pk
EUR 347

Custom Peptide Conjugation to KLH/BSA/Ovalbumin or agarose (mg-100 mg size, price based upon servicesa)

CONJ-1 1 Ask for price

Urokinase protein

30C-CP8107 50 ug
EUR 405
Description: Purified Recombinant Human Urokinase protein

Urokinase Antibody

49439-100ul 100ul
EUR 333

Urokinase Antibody

49439-50ul 50ul
EUR 239

Urokinase antibody

5793-100
EUR 338

Urokinase antibody

5793-30T
EUR 146

Urokinase Antibody

abx024172-200ul 200 ul
EUR 578
  • Shipped within 5-10 working days.

Accuris 1 Hour Mammalian Genotyping Kit

PR1300-MG-400 1 PC
EUR 453.38
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Accuris 1 Hour Mammalian Genotyping Kit

PR1300-MG-80 1 PC
EUR 154.32
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Accuris 1 Hour Mammalian Genotyping Kit

PR1300-MG-S 1 PC
EUR 71.38
  • To order instruments in 115V / US plug please delete the 'E' off the order code.European 2 pin plugs will be supplied as standard, please request UK if required.

Human Urokinase (uPA) Antibody

11651-05011 150 ug
EUR 217

Human Urokinase ELISA kit

E01U0010-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit

E01U0010-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit

E01U0010-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pro-Urokinase, human recombinant

7695-10
EUR 202

Pro-Urokinase, human recombinant

7695-50
EUR 479

Pro-Urokinase, human recombinant

7695-500
EUR 1675

CF405S monoclonal mouse anti-biotin IgG, 2 mg/mL

20203-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF488A monoclonal mouse anti-biotin IgG, 2 mg/mL

20204-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF594 monoclonal mouse anti-biotin IgG, 2 mg/mL

20205-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF633 monoclonal mouse anti-biotin IgG, 2 mg/mL

20206-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF640R monoclonal mouse anti-biotin IgG, 2 mg/mL

20207-1 50uL
EUR 149
Description: Minimum order quantity: 1 unit of 50uL

Human ?1-microglobulin,?1-MG ELISA Kit

201-12-1093 96 tests
EUR 440
  • This alpha 1-microglobulin ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Cyanine3 azide, 1 mg

A1030 1 mg
EUR 108

Cyanine3 alkyne, 1 mg

A10B0 1 mg
EUR 108

Cyanine3 DBCO, 1 mg

A10F0 1 mg
EUR 108

Cyanine3 hydrazide, 1 mg

11070 1 mg
EUR 108

Cyanine3 maleimide, 1 mg

11080 1 mg
EUR 108

Cyanine3 amine, 1 mg

110C0 1 mg
EUR 108

Cyanine5 hydrazide, 1 mg

13070 1 mg
EUR 108

Cyanine5 maleimide, 1 mg

13080 1 mg
EUR 108

Cyanine5 amine, 1 mg

130C0 1 mg
EUR 108

Pyrene hydrazide, 1 mg

13570 1 mg
EUR 108

Pyrene maleimide, 1 mg

13580 1 mg
EUR 108

Cyanine7 tetrazine, 1 mg

150 1 mg
EUR 108

Cyanine7 hydrazide, 1 mg

15070 1 mg
EUR 108

Cyanine7 maleimide, 1 mg

15080 1 mg
EUR 108

Cyanine7 amine, 1 mg

150C0 1 mg
EUR 108

Cyanine7.5 hydrazide, 1 mg

16070 1 mg
EUR 108

Cyanine7.5 maleimide, 1 mg

16080 1 mg
EUR 108

Cyanine7.5 amine, 1 mg

160C0 1 mg
EUR 108

Cyanine5.5 hydrazide, 1 mg

17070 1 mg
EUR 108

Cyanine5.5 maleimide, 1 mg

17080 1 mg
EUR 108

Cyanine5.5 amine, 1 mg

170C0 1 mg
EUR 108

Pepsin, 1 mg, lyophilized

6011 1 mg
EUR 63.05
Description: Pepsin

Cyanine5.5 azide, 1 mg

A4030 1 mg
EUR 108

Cyanine7.5 azide, 1 mg

A6030 1 mg
EUR 108

Cyanine7.5 alkyne, 1 mg

A60B0 1 mg
EUR 108

Cyanine5.5 alkyne, 1 mg

A70B0 1 mg
EUR 108

Cyanine5.5 DBCO, 1 mg

A70F0 1 mg
EUR 108

Cyanine5 alkyne, 1 mg

A30B0 1 mg
EUR 108

Cyanine5 DBCO, 1 mg

A30F0 1 mg
EUR 108

Cyanine7 azide, 1 mg

A5030 1 mg
EUR 108

Cyanine7 alkyne, 1 mg

A50B0 1 mg
EUR 108

Cyanine7 DBCO, 1 mg

A50F0 1 mg
EUR 108

Perylene azide, 1 mg

A5530 1 mg
EUR 108

Cyanine3.5 azide, 1 mg

A2030 1 mg
EUR 108

Cyanine5 azide, 1 mg

A3030 1 mg
EUR 108

PEP azide, 1 mg

A4530 1 mg
EUR 108

Pyrene azide 1, 1 mg

A1530 1 mg
EUR 108

Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size)

20007-1-BL-1 10 ml Ask for price

Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody (Biotin Conjugate)

11661-05021 150 ug
EUR 276

Human Anti-NKX3.1 IgG, 1 mg

314 1 mg
EUR 480

CF488A Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20071-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF594 Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20072-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF488A Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20074-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF594 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20075-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF633 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20076-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF640R goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20081-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20097-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20132-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20154-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF555 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20230-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF647 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20280-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF647 rabbit anti-goat IgG(H+L), 2 mg/mL

20049-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660C goat anti-mouse IgG(H+L), 2 mg/mL

20050-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660C goat anti-rabbit IgG(H+L), 2 mg/mL

20053-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660R goat anti-mouse IgG(H+L), 2 mg/mL

20054-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660R goat anti-rabbit IgG(H+L), 2 mg/mL

20055-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF680 rabbit anti-goat IgG(H+L), 2 mg/mL

20068-1 50uL
EUR 132
Description: Minimum order quantity: 1 unit of 50uL

CF750 goat anti-mouse IgG(H+L), 2 mg/mL

20070-1 50uL
EUR 132
Description: Minimum order quantity: 1 unit of 50uL

CF750 goat anti-rabbit IgG(H+L), 2 mg/mL

20073-1 50uL
EUR 132
Description: Minimum order quantity: 1 unit of 50uL

CF405S goat anti-mouse IgG(H+L), 2 mg/mL

20080-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF405S goat anti-rabbit IgG(H+L), 2 mg/mL

20082-1 50ul
EUR 120
Description: Minimum order quantity: 1 unit of 50ul

CF640R goat anti-swine IgG(H+L), 2 mg/mL

20089-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF640R rabbit anti-goat IgG(H+L), 2 mg/mL

20090-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-swine IgG(H+L), 2 mg/mL

20091-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-mouse IgG(H+L), 2 mg/mL

20100-1 50ul
EUR 120
Description: Minimum order quantity: 1 unit of 50ul

CF568 goat anti-rabbit IgG(H+L), 2 mg/mL

20102-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF568 rabbit anti-goat IgG(H+L), 2 mg/mL

20107-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-mouse IgG(H+L), 2 mg/mL

20110-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-rabbit IgG(H+L), 2 mg/mL

20112-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-mouse IgG(H+L), 2 mg/mL

20120-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-rabbit IgG(H+L), 2 mg/mL

20122-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 rabbit anti-goat IgG(H+L), 2 mg/mL

20128-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-swine IgG(H+L), 2 mg/mL

20138-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF350 goat anti-mouse IgG(H+L), 2 mg/mL

20140-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF350 goat anti-rabbit IgG(H+L), 2 mg/mL

20141-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-swine IgG(H+L), 2 mg/mL

20160-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF405M goat anti-mouse IgG(H+L), 2 mg/mL

20180-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF405M goat anti-rabbit IgG(H+L), 2 mg/mL

20181-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

Biotin goat anti-mouse IgG(H+L), 2 mg/mL

20183-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

Biotin goat anti-rabbit IgG(H+L), 2 mg/mL

20185-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF640R goat anti-mouse IgG(H+L), 2 mg/mL

20197-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF640R goat anti-rabbit IgG(H+L), 2 mg/mL

20202-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF488A chicken anti-mouse IgG(H+L), 2 mg/mL

20208-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF488A chicken anti-rabbit IgG(H+L), 2 mg/mL

20209-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF488A monoclonal mouse anti-fluorescein (FITC) IgG, 2 mg/mL

20210-1 50uL
EUR 161
Description: Minimum order quantity: 1 unit of 50uL

CF594 chicken anti-mouse IgG(H+L), 2 mg/mL

20221-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

CF633 chicken anti-mouse IgG(H+L), 2 mg/mL

20222-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

CF594 chicken anti-rabbit IgG(H+L), 2 mg/mL

20223-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

CF633 chicken anti-rabbit IgG(H+L), 2 mg/mL

20224-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

CF488A chicken anti-goat IgG(H+L), 2 mg/mL

20225-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

CF594 chicken anti-goat IgG(H+L), 2 mg/mL

20226-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

CF633 chicken anti-goat IgG(H+L), 2 mg/mL

20227-1 50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL

After multivariate adjustment, Supar ≥2.6 ng / mL were independently associated with an increased risk of all-cause mortality (HR 2.3; 95% CI 1.2 to 4.4; p = 0.017), major adverse cardiovascular events (MACE) ( HR 1.7; 95% CI 1.1 to 2.5; p = 0.020) and heart failure (HR 4.1; 95% CI 1.3 to 12.6; p = 0.015), but not with myocardial infarction , For long-term all-cause mortality significant increase of reclassification and discrimination Supar look after addition to the clinical model.

Dustin

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