N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

poison ligand-targeted (LTTs) are artificial molecules that consist of a targeting component associated with the toxins that induce cell death after binding targets LTT. targeting bispecific allows for the simultaneous targeting of two receptors. In this review, we mostly focus on epidermal growth factor receptor (EGFR) as a target. We discuss the development and testing of LTT bispecific targeting EGFR and urokinase-type plasminogen activator receptor (Upar) as two attractive targets involved in tumor growth and in the regulation of the tumor microvasculature in solid tumors. In vitro and mouse xenograft studies have demonstrated that EGFR-targeted bispecific angiotoxin (eBAT) effective against human solid tumors. Studies have shown that eBAT dog is safe and effective against canine hemangiosarcoma, which are physiologically similar to human angiosarcoma.

Finding the right dose strategy and sequencing eBAT administration, in combination with other therapies, among the factors important for the future direction. Together, the data suggest that stem cells eBAT cancer targets, may have a role in inhibiting tumor blood vessels, human, and bispecific conformations that may have a role in reducing the toxicity of the oncologic comparative trials in dogs.
The urokinase plasminogen activator and its receptor (uPA / Upar) is a biomarker for metastasis, particularly in triple-negative breast cancer.

We set up an anti-mitotic N-alkylisatin (N-AI) -loaded liposomes functionalized with uPA / Upar targeting ligand, plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2), and rated liposome uptake in vitro and in vivo. receptor dependent uptake of liposome-functionalized PAI-2 was significantly higher in the uPA / Upar overexpressing MDA-MB-231 breast cancer cells is relatively low Upar / Upar expressing MCF-7 breast cancer cells. Furthermore, N-AI cytotoxicity enhanced by receptor-dependent manner.

In vivo, PAI-2 N-AI liposomes have a plasma half-life of 5.82 h and showed increased accumulation at the primary tumor site in the MDA-MB-231 BALB / c-Fox1nu / Ausb mouse orthotopic xenograft model, relative to non-functionalized liposome , up to 6 hours post injection. These findings support the further development of the N-AI-loaded liposomes PAI-2-enabled for breast cancer uPA / Upar-positive, especially against triple-negative breast cancer, the prognosis is poor and treatment is limited.

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer
N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

Soluble urokinase plasminogen activator receptor as a prognostic biomarker for long-term acute coronary syndrome

Objective: The aim of our study was to analyze the long-term prognostic value soluble urokinase plasminogen activator receptor (Supar) in the setting of acute coronary syndromes (ACS) .Methods: We included 340 patients with ACS undergoing coronary angiography and plasma concentrations were measured Supar. Patients were classified into Supar low concentrations (<2.6 ng / mL) and high Supar concentration (≥2.6 ng / mL) and long-term events are evaluated.

Supar rated prognostic value beyond the clinical model that included age, GRACE score, estimated glomerular filtration rate, cardiac troponin-I peak and left ventricular ejection fraction <40% .Results: Higher concentrations Supar associated with an increased prevalence of cardiovascular risk factors.

Human Urokinase

21560039-1 100 µg
EUR 154.66

Human Urokinase

7-03802 100µg Ask for price

Human Urokinase

7-03803 1mg Ask for price

Human Urokinase

7-03804 5mg Ask for price

Human Urokinase

RP-1463 100 ug
EUR 196.8

Human Urokinase

MBS142405-01mg 0.1mg
EUR 310

Human Urokinase

MBS142405-1mg 1mg
EUR 485

Human Urokinase

MBS142405-5mg 5mg
EUR 1260

Human Urokinase

MBS142405-5x5mg 5x5mg
EUR 5345

Urokinase, Human Urine

MBS653743-01mg 0.1mg
EUR 470

Urokinase, Human Urine

MBS653743-1mg 1mg
EUR 795

Urokinase, Human Urine

MBS653743-5x1mg 5x1mg
EUR 3430

Urokinase, Human urine

HY-108904 5 mg
EUR 541.13
Description: Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research[1].

Urokinase, human recombinant

7696-10 each
EUR 261.6

Urokinase, human recombinant

7696-50 each
EUR 652.8

Urokinase, human recombinant

7696-500 each
EUR 2271.6

Urokinase Human Recombinant

rAP-1424 Inquiry Ask for price

Human LMW urokinase

MBS135608-01mg 0.1mg
EUR 540

Human LMW urokinase

MBS135608-1mg 1mg
EUR 3440

Human LMW urokinase

MBS135608-5x1mg 5x1mg
EUR 15240

Human HMW Urokinase

MBS135613-01mg 0.1mg
EUR 450

Human HMW Urokinase

MBS135613-1mg 1mg
EUR 2945

Human HMW Urokinase

MBS135613-5x1mg 5x1mg
EUR 13010

Human Urokinase (HMW)

MBS480672-01mg 0.1mg
EUR 515

Human Urokinase (HMW)

MBS480672-5x01mg 5x0.1mg
EUR 2100

Human Urokinase (LMW)

MBS480676-01mg 0.1mg
EUR 625

Human Urokinase (LMW)

MBS480676-5x01mg 5x0.1mg
EUR 2595

840 Urokinase human 20 ug

840 20 ug
EUR 218.9

Human Urokinase (LMW) HRP

MBS480677-01mg 0.1mg
EUR 790

Human Urokinase (LMW) HRP

MBS480677-5x01mg 5x0.1mg
EUR 3315

Recombinant Human Urokinase

MBS147135-0001mg 0.001mg
EUR 240

Recombinant Human Urokinase

MBS147135-0005mg 0.005mg
EUR 310

Recombinant Human Urokinase

MBS147135-005mg 0.05mg
EUR 1360

Recombinant Human Urokinase

MBS147135-5x005mg 5x0.05mg
EUR 5800

Immobilized human urokinase

MBS135763-1mL 1mL
EUR 845

Immobilized human urokinase

MBS135763-5x1mL 5x1mL
EUR 3565

Immobilized human urokinase

MBS480749-1mL 1mL
EUR 940

Immobilized human urokinase

MBS480749-5x1mL 5x1mL
EUR 4025

Urokinase Mixed Human 95%

GWB-37FE97 10000 Unit Ask for price

Human Urokinase (LMW) FITC

MBS480678-01mg 0.1mg
EUR 790

Human Urokinase (LMW) FITC

MBS480678-5x01mg 5x0.1mg
EUR 3315

Human Urokinase ELISA kit

E01A8524 96T
EUR 700
Description: ELISA

Human Urokinase ELISA kit

E01U0010-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit

E01U0010-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit

E01U0010-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA Kit

MBS036509-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Urokinase ELISA Kit

MBS036509-48StripWells 48-Strip-Wells
EUR 550

Human Urokinase ELISA Kit

MBS036509-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Urokinase ELISA Kit

MBS036509-96StripWells 96-Strip-Wells
EUR 765

Human Urokinase ELISA Kit

NSL0190Hu 96 wells
EUR 468

Human Urokinase ELISA Kit

MBS730916-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Urokinase ELISA Kit

MBS730916-48StripWells 48-Strip-Wells
EUR 485

Human Urokinase ELISA Kit

MBS730916-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human Urokinase ELISA Kit

MBS730916-96StripWells 96-Strip-Wells
EUR 690

Human Urokinase ELISA Kit

MBS266519-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human Urokinase ELISA Kit

MBS266519-48StripWells 48-Strip-Wells
EUR 285

Human Urokinase ELISA Kit

MBS266519-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human Urokinase ELISA Kit

MBS266519-96StripWells 96-Strip-Wells
EUR 405

Human Urokinase ELISA Kit

EIA06502h each
EUR 430

Human Urokinase, HRP Labeled

MBS480674-01mg 0.1mg
EUR 790

Human Urokinase, HRP Labeled

MBS480674-5x01mg 5x0.1mg
EUR 3315

Human Urokinase (uPA) Antibody

11651-05011 150 ug
EUR 175

Human Urokinase GENLISA ELISA

KBH0801 1 x 96 wells
EUR 286

Human Urokinase (UK) ELISA Kit

EK12113 96Т
EUR 799

Human Urokinase (UK) ELISA Kit

AE63105HU-48Tests 48 Tests
EUR 360
Description: Human (Homo sapiens)

Human Urokinase (UK) ELISA Kit

AE63105HU-96Tests 96 Tests
EUR 680
Description: Human (Homo sapiens)

Human urokinase,UK ELISA Kit

CN-04011H1 96T
EUR 520.8

Human urokinase,UK ELISA Kit

CN-04011H2 48T
EUR 340.8

Human urokinase,UK ELISA Kit

YLA2411HU-48T 48T Ask for price

Human urokinase,UK ELISA Kit

YLA2411HU-96T 96T Ask for price

Human urokinase(UK)ELISA Kit

GA-E0818HM-48Tests 48 Tests Ask for price

Human urokinase(UK)ELISA Kit

GA-E0818HM-96Tests 96 Tests
EUR 388

Human urokinase,UK ELISA KIT

E0801Hu-1096T 10*96T
EUR 4122

Human urokinase,UK ELISA KIT

E0801Hu-48wells 48 wells
EUR 300

Human urokinase,UK ELISA KIT

E0801Hu-596T 5*96T
EUR 2061

Human urokinase,UK ELISA KIT

E0801Hu-96wells 96 wells
EUR 458

Human urokinase(UK)ELISA Kit

GA-E0818HM-48T 48T
EUR 346.8

Human urokinase(UK)ELISA Kit

GA-E0818HM-96T 96T
EUR 559.2

Human urokinase(UK)ELISA Kit

QY-E02059 96T
EUR 433.2

Human Urokinase, UK ELISA Kit

SL1797Hu 96 Tests
EUR 468

Human Urokinase (UK) ELISA Kit

AE63105HU-48T 48T
EUR 360
Description: Human (Homo sapiens)

Human Urokinase (UK) ELISA Kit

AE63105HU-96T 96T
EUR 680
Description: Human (Homo sapiens)

Human urokinase, UK ELISA Kit

MBS161707-10x96StripWells 10x96-Strip-Wells
EUR 3460

Human urokinase, UK ELISA Kit

MBS161707-48StripWells 48-Strip-Wells
EUR 285

Human urokinase, UK ELISA Kit

MBS161707-5x96StripWells 5x96-Strip-Wells
EUR 1750

Human urokinase, UK ELISA Kit

MBS161707-96StripWells 96-Strip-Wells
EUR 425

Human Urokinase (UK) ELISA Kit

MBS3801099-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Urokinase (UK) ELISA Kit

MBS3801099-48StripWells 48-Strip-Wells
EUR 550

Human Urokinase (UK) ELISA Kit

MBS3801099-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Urokinase (UK) ELISA Kit

MBS3801099-96StripWells 96-Strip-Wells
EUR 765

Human urokinase,UK ELISA Kit

201-12-0802 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Purified native Human Urokinase

MBS5308445-01mg 0.1mg
EUR 500

Purified native Human Urokinase

MBS5308445-5x01mg 5x0.1mg
EUR 2205

Human Urokinase/uPA ELISA Kit

E28L0631 96T
EUR 666.67

*Human Urokinase (uPA) ELISA Kit

IHUUPAKT each
EUR 528
Description: *Human Urokinase (uPA) ELISA Kit

811 Goat anti-human urokinase polyclonal antibody 0.1 mg

811 0.1 mg
EUR 157.3

168 Rabbit anti-human urokinase polyclonal antibody 0.5 mg

168 0.5 mg
EUR 382.8

Human HMW urokinase, HRP conjugate

MBS135617-01mg 0.1mg
EUR 720

Human HMW urokinase, HRP conjugate

MBS135617-1mg 1mg
EUR 4550

Human LMW urokinase, HRP conjugate

MBS135606-01mg 0.1mg
EUR 720

Human LMW urokinase, HRP conjugate

MBS135606-1mg 1mg
EUR 4550

Human HMW urokinase, biotin labeled

MBS135995-01mg 0.1mg
EUR 750

Human HMW urokinase, biotin labeled

MBS135995-1mg 1mg
EUR 4775

ELISA kit for Human Urokinase (UK)

KTE62644-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human Urokinase (UK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Urokinase (UK)

KTE62644-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human Urokinase (UK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Urokinase (UK)

KTE62644-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human Urokinase (UK) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Urokinase

30R-2710 100 ug
EUR 367
Description: Purified native Human Urokinase

Urokinase

4793-100 each
EUR 385.2

Urokinase,

4793-1000 each
EUR 1618.8

Urokinase

E8ET1703-26 100ul
EUR 275
Description: Available in various conjugation types.

Urokinase

enz-264 100µg
EUR 145
Description: Human Urokinase

Urokinase

enz-965 1µg
EUR 60
Description: Recombinant Human Urokinase

Urokinase

MBS8534429-01mL 0.1mL
EUR 345

Urokinase

MBS8534429-01mLAF405L 0.1mL(AF405L)
EUR 565

Urokinase

MBS8534429-01mLAF405S 0.1mL(AF405S)
EUR 565

Urokinase

MBS8534429-01mLAF610 0.1mL(AF610)
EUR 565

Urokinase

MBS8534429-01mLAF635 0.1mL(AF635)
EUR 565

Urokinase

THP-0021 1 vial
EUR 3198.4
Description: Protein

*Human Total Urokinase (uPA) ELISA Kit

IHUUPAKTT each
EUR 528
Description: *Human Total Urokinase (uPA) ELISA Kit

Urokinase, Amino Terminal Fragment, Human

MBS653996-01mg 0.1mg
EUR 1175

Urokinase, Amino Terminal Fragment, Human

MBS653996-5x01mg 5x0.1mg
EUR 5055

Human HMW urokinase, fluorescein labeled

MBS135622-01mg 0.1mg
EUR 720

Human HMW urokinase, fluorescein labeled

MBS135622-1mg 1mg
EUR 4550

Human LMW urokinase, fluorescein labeled

MBS135604-01mg 0.1mg
EUR 720

Human LMW urokinase, fluorescein labeled

MBS135604-1mg 1mg
EUR 4550

Human Urokinase/uPA Antibody Pair Set

ABPR-ZB025 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human Urokinase/uPA

*Human PAI-1 and Urokinase (uPA) Complex ELISA Kit

IHUPAI1UPAKTCX each
EUR 528
Description: *Human PAI-1 and Urokinase (uPA) Complex ELISA Kit

*Human Urokinase (uPA) Purified Immobilized

IHUUPAIMM1ML each
EUR 604
Description: *Human Urokinase (uPA) Purified Immobilized

Recombinant Human Urokinase/PLAU Protein

MBS9144001-0005mg 0.005mg
EUR 225

Recombinant Human Urokinase/PLAU Protein

MBS9144001-002mg 0.02mg
EUR 300

Recombinant Human Urokinase/PLAU Protein

MBS9144001-005mg 0.05mg
EUR 380

After multivariate adjustment, Supar ≥2.6 ng / mL were independently associated with an increased risk of all-cause mortality (HR 2.3; 95% CI 1.2 to 4.4; p = 0.017), major adverse cardiovascular events (MACE) ( HR 1.7; 95% CI 1.1 to 2.5; p = 0.020) and heart failure (HR 4.1; 95% CI 1.3 to 12.6; p = 0.015), but not with myocardial infarction , For long-term all-cause mortality significant increase of reclassification and discrimination Supar look after addition to the clinical model.

Dustin

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