N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

poison ligand-targeted (LTTs) are artificial molecules that consist of a targeting component associated with the toxins that induce cell death after binding targets LTT. targeting bispecific allows for the simultaneous targeting of two receptors. In this review, we mostly focus on epidermal growth factor receptor (EGFR) as a target. We discuss the development and testing of LTT bispecific targeting EGFR and urokinase-type plasminogen activator receptor (Upar) as two attractive targets involved in tumor growth and in the regulation of the tumor microvasculature in solid tumors. In vitro and mouse xenograft studies have demonstrated that EGFR-targeted bispecific angiotoxin (eBAT) effective against human solid tumors. Studies have shown that eBAT dog is safe and effective against canine hemangiosarcoma, which are physiologically similar to human angiosarcoma.

Finding the right dose strategy and sequencing eBAT administration, in combination with other therapies, among the factors important for the future direction. Together, the data suggest that stem cells eBAT cancer targets, may have a role in inhibiting tumor blood vessels, human, and bispecific conformations that may have a role in reducing the toxicity of the oncologic comparative trials in dogs.
The urokinase plasminogen activator and its receptor (uPA / Upar) is a biomarker for metastasis, particularly in triple-negative breast cancer.

We set up an anti-mitotic N-alkylisatin (N-AI) -loaded liposomes functionalized with uPA / Upar targeting ligand, plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2), and rated liposome uptake in vitro and in vivo. receptor dependent uptake of liposome-functionalized PAI-2 was significantly higher in the uPA / Upar overexpressing MDA-MB-231 breast cancer cells is relatively low Upar / Upar expressing MCF-7 breast cancer cells. Furthermore, N-AI cytotoxicity enhanced by receptor-dependent manner.

In vivo, PAI-2 N-AI liposomes have a plasma half-life of 5.82 h and showed increased accumulation at the primary tumor site in the MDA-MB-231 BALB / c-Fox1nu / Ausb mouse orthotopic xenograft model, relative to non-functionalized liposome , up to 6 hours post injection. These findings support the further development of the N-AI-loaded liposomes PAI-2-enabled for breast cancer uPA / Upar-positive, especially against triple-negative breast cancer, the prognosis is poor and treatment is limited.

N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer
N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer

Soluble urokinase plasminogen activator receptor as a prognostic biomarker for long-term acute coronary syndrome

Objective: The aim of our study was to analyze the long-term prognostic value soluble urokinase plasminogen activator receptor (Supar) in the setting of acute coronary syndromes (ACS) .Methods: We included 340 patients with ACS undergoing coronary angiography and plasma concentrations were measured Supar. Patients were classified into Supar low concentrations (<2.6 ng / mL) and high Supar concentration (≥2.6 ng / mL) and long-term events are evaluated.

Supar rated prognostic value beyond the clinical model that included age, GRACE score, estimated glomerular filtration rate, cardiac troponin-I peak and left ventricular ejection fraction <40% .Results: Higher concentrations Supar associated with an increased prevalence of cardiovascular risk factors.

Human Urokinase

7-03802 100µg Ask for price

Human Urokinase

7-03803 1mg Ask for price

Human Urokinase

7-03804 5mg Ask for price

Human Urokinase

RP-1463 100 ug
EUR 196.8

MG 1

HY-U00110 5mg
EUR 721.2

Human Genomic DNA 

X11000
  • Ask for price
  • EUR 235.40
  • 0.2 ml
  • 0.2 ml

Human Brain Genomic DNA  

X11001
  • Ask for price
  • EUR 77.00
  • 10 µg
  • 10 ul

Monoolien-9 (100 mg)

MLCP-RMO9-1 100 mg
EUR 95
Description: Monoolien-9 (100 mg)

Urokinase

30R-2710 100 ug
EUR 507.6
Description: Purified native Human Urokinase

Urokinase

4793-100
EUR 385.2

Urokinase,

4793-1000
EUR 1618.8

Urokinase, human recombinant

7696-10
EUR 261.6

Urokinase, human recombinant

7696-50
EUR 652.8

Urokinase, human recombinant

7696-500
EUR 2271.6

rRTF (1-mg)*

41055-2 1mg
EUR 1009.78

Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody

11661-05011 150 ug
EUR 260.4

Custom Peptide Conjugation to KLH/BSA/Ovalbumin or agarose (mg-100 mg size, price based upon servicesa)

CONJ-1 1 Ask for price

Synthetic Adjuvant Combo Pak-1 (contains 1 mg of Gardiquimod (#AV-8010), Imiquimod (#AV-8015) and 1 mg R848 (#AV-8020-1)

AV-8000-PK-1 1 pk
EUR 416.4

Accuris 1 Hour Mammalian Genotyping Kit

PR1300-MG-400 1 PC
EUR 544.06

Accuris 1 Hour Mammalian Genotyping Kit

PR1300-MG-80 1 PC
EUR 185.18

Accuris 1 Hour Mammalian Genotyping Kit

PR1300-MG-S 1 PC
EUR 85.66

Urokinase antibody

5793-100
EUR 405.6

Urokinase antibody

5793-30T
EUR 175.2

Urokinase protein

30C-CP8107 50 ug
EUR 486
Description: Purified Recombinant Human Urokinase protein

Urokinase Antibody

49439-100ul 100ul
EUR 399.6

Urokinase Antibody

49439-50ul 50ul
EUR 286.8

Urokinase Antibody

abx024172-200ul 200 ul
EUR 693.6

Urokinase Antibody

F51093-0.4ML 0.4 ml
EUR 379

Urokinase Antibody

F52084-0.4ML 0.4 ml
EUR 379

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag

E80025
  • EUR 635.80
  • EUR 3934.70
  • 100 ul
  • 1 ml

Human Urokinase (uPA) Antibody

11651-05011 150 ug
EUR 260.4

Pro-Urokinase, human recombinant

7695-10
EUR 242.4

Pro-Urokinase, human recombinant

7695-50
EUR 574.8

Pro-Urokinase, human recombinant

7695-500
EUR 2010

Human Urokinase ELISA kit

E01U0010-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit

E01U0010-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit

E01U0010-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase-type plasminogen activator (PLAU)

1-CSB-RP143194h(A4)
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Urokinase-type plasminogen activator(PLAU),partial expressed in E.coli

CF405S monoclonal mouse anti-biotin IgG, 2 mg/mL

20203-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF488A monoclonal mouse anti-biotin IgG, 2 mg/mL

20204-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF594 monoclonal mouse anti-biotin IgG, 2 mg/mL

20205-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF633 monoclonal mouse anti-biotin IgG, 2 mg/mL

20206-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF640R monoclonal mouse anti-biotin IgG, 2 mg/mL

20207-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

Histone H3 Methylation Antibody Panel Pack I – Active Genes

C10000
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
  • 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack I – Repression Genes

C10001
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
  • 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack II – Active Genes

C10002
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3 Methylation Antibody Panel Pack II – Repression Genes

C10003
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
  • 4 x 25 ul

Histone H3 Methylation Antibody Panel Pack III – Active Genes

C10004
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
  • 4 x 25 ul

Histone H3K4 Methylation Antibody Panel Pack

C10005
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3K9 Methylation Antibody Panel Pack

C10006
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3K27 Methylation Antibody Panel Pack

C10007
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3K36 Methylation Antibody Panel Pack

C10008
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3K79 Methylation Antibody Panel Pack

C10009
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3 Acetylation Antibody Panel Pack I

C10010
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
  • 4 x 25 ul

Histone H3 Acetylation Antibody Panel Pack II

C10011
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
  • 4 x 25 ul

Histone H4K20 Methylation Antibody Panel Pack

C10012
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H4 Acetylation Antibody Panel Pack

C10013
  • EUR 754.26
  • EUR 470.80
  • 4 x 25 µg
  • 4 x 25 ul

Histone H3 Phosphorylation Antibody Panel Pack

C10014
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3R2 Methylation Antibody Panel Pack

C10015
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3R8 Methylation Antibody Panel Pack

C10016
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3R17 Methylation Antibody Panel Pack

C10017
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H3R26 Methylation Antibody Panel Pack

C10018
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H4R3 Methylation Antibody Panel Pack

C10019
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

DNA Methylation Antibody Panel Pack I

C20000
  • EUR 458.46
  • EUR 270.60
  • 2 x 25 ul

DNMT3A Protein

E11000
  • EUR 971.76
  • EUR 618.20
  • 10 µg
  • 10 ul

TET1 Protein (Active)

E12002
  • EUR 387.12
  • EUR 225.50
  • 10 µg
  • 10 ul

DNMT3B Protein 

E14000
  • EUR 971.76
  • EUR 618.20
  • 10 µg
  • 10 ul

DNMT1 Protein 

E15000
  • EUR 971.76
  • EUR 618.20
  • 10 µg
  • 10 ul

HDAC1 Protein 

E24002
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC10 Protein 

E24003
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC11 Protein 

E24004
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC2 Protein 

E24005
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC3 Protein 

E24006
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC4 Protein 

E24007
  • EUR 968.28
  • EUR 616.00
  • 10 µg
  • 10 ul

HDAC5 Protein 

E24008
  • EUR 968.28
  • EUR 616.00
  • 10 µg
  • 10 ul

HDAC6 Protein 

E24009
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC7 Protein 

E24010
  • EUR 968.28
  • EUR 616.00
  • 10 µg
  • 10 ul

HDAC8 Protein 

E24011
  • EUR 968.28
  • EUR 616.00
  • 50 µg
  • 50 ul

HDAC9 Protein 

E24012
  • EUR 968.28
  • EUR 616.00
  • 10 µg
  • 10 ul

H3F3A Protein 

E35003
  • EUR 174.84
  • EUR 78.10
  • 50 µg
  • 50 ul

H4 Protein 

E35005
  • EUR 174.84
  • EUR 78.10
  • 50 µg
  • 50 ul

SOD1 Protein 

E70000
  • EUR 599.40
  • EUR 365.20
  • 25 µg
  • 25 ul

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated

A12001
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Goat Anti-Rat Secondary Antibody, Biotin Conjugated

A12002
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

HRP-Goat Anti-Mouse Secondary Antibody

A12003
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

HRP-Goat Anti-Rabbit Secondary Antibody

A12004
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

EpiMag HT (96-Well) Magnetic Separator

Q10002
  • EUR 416.70
  • EUR 258.50
  • 1/Pack
  • 1/Pack

EpiMag 96-Well Microplate (5/pack) 

Q10003
  • EUR 136.56
  • EUR 52.80
  • 5/pack
  • 5/pack

Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size)

20007-1-BL-1 10 ml Ask for price

Human ?1-microglobulin,?1-MG ELISA Kit

201-12-1093 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

CF633 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20132-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20154-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF555 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20230-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF647 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20280-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF488A goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20022-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF488A Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20071-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF594 Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20072-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF488A Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20074-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF594 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20075-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF633 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20076-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF640R goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20081-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL

20097-1 50uL
EUR 164.4
Description: Minimum order quantity: 1 unit of 50uL

Pepsin, 1 mg, lyophilized

6011 1 mg
EUR 75.66
Description: Pepsin

Cyanine3 maleimide, 1 mg

11080 1 mg
EUR 129.6

Cyanine3 amine, 1 mg

110C0 1 mg
EUR 129.6

Pyrene hydrazide, 1 mg

13570 1 mg
EUR 129.6

Pyrene maleimide, 1 mg

13580 1 mg
EUR 129.6

Cyanine5 hydrazide, 1 mg

13070 1 mg
EUR 129.6

Cyanine5 maleimide, 1 mg

13080 1 mg
EUR 129.6

Cyanine5 amine, 1 mg

130C0 1 mg
EUR 129.6

Cyanine3 azide, 1 mg

A1030 1 mg
EUR 129.6

Cyanine3 alkyne, 1 mg

A10B0 1 mg
EUR 129.6

Cyanine3 DBCO, 1 mg

A10F0 1 mg
EUR 129.6

Cyanine5.5 amine, 1 mg

170C0 1 mg
EUR 129.6

Cyanine7 hydrazide, 1 mg

15070 1 mg
EUR 129.6

Cyanine7 maleimide, 1 mg

15080 1 mg
EUR 129.6

Cyanine7 amine, 1 mg

150C0 1 mg
EUR 129.6

Cyanine7.5 maleimide, 1 mg

16080 1 mg
EUR 129.6

Cyanine7.5 amine, 1 mg

160C0 1 mg
EUR 129.6

Cyanine5 azide, 1 mg

A3030 1 mg
EUR 129.6

Cyanine5 alkyne, 1 mg

A30B0 1 mg
EUR 129.6

Cyanine5 DBCO, 1 mg

A30F0 1 mg
EUR 129.6

Cyanine5.5 azide, 1 mg

A4030 1 mg
EUR 129.6

PEP azide, 1 mg

A4530 1 mg
EUR 129.6

Cyanine5.5 alkyne, 1 mg

A70B0 1 mg
EUR 129.6

Cyanine5.5 DBCO, 1 mg

A70F0 1 mg
EUR 129.6

Cyanine7 alkyne, 1 mg

A50B0 1 mg
EUR 129.6

Cyanine7 DBCO, 1 mg

A50F0 1 mg
EUR 129.6

Cyanine7.5 azide, 1 mg

A6030 1 mg
EUR 129.6

Cyanine7.5 alkyne, 1 mg

A60B0 1 mg
EUR 129.6

Cyanine3.5 azide, 1 mg

A2030 1 mg
EUR 129.6

After multivariate adjustment, Supar ≥2.6 ng / mL were independently associated with an increased risk of all-cause mortality (HR 2.3; 95% CI 1.2 to 4.4; p = 0.017), major adverse cardiovascular events (MACE) ( HR 1.7; 95% CI 1.1 to 2.5; p = 0.020) and heart failure (HR 4.1; 95% CI 1.3 to 12.6; p = 0.015), but not with myocardial infarction , For long-term all-cause mortality significant increase of reclassification and discrimination Supar look after addition to the clinical model.

Dustin

Related Posts

Comparison of intrapleural use of urokinase and tissue plasminogen activator/DNAse in pleural infection.

Comparison of intrapleural use of urokinase and tissue plasminogen activator/DNAse in pleural infection.

Serum plasminogen activator urokinase receptor predicts elevated risk of acute respiratory distress syndrome in patients with sepsis and is positively associated with disease severity, inflammation and mortality.

Serum plasminogen activator urokinase receptor predicts elevated risk of acute respiratory distress syndrome in patients with sepsis and is positively associated with disease severity, inflammation and mortality.

Comparative study on the efficacy and safety of alteplase and urokinase in the treatment of acute cerebral infarction

Comparative study on the efficacy and safety of alteplase and urokinase in the treatment of acute cerebral infarction

Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase-type plasminogen activator receptor levels

Independent impact of periodontitis and cardiovascular disease on elevated soluble urokinase-type plasminogen activator receptor levels

No Comment

Leave a Reply

Your email address will not be published.

January 2023
M T W T F S S
 1
2345678
9101112131415
16171819202122
23242526272829
3031  

Recent Posts

Categories

Tags