poison ligand-targeted (LTTs) are artificial molecules that consist of a targeting component associated with the toxins that induce cell death after binding targets LTT. targeting bispecific allows for the simultaneous targeting of two receptors. In this review, we mostly focus on epidermal growth factor receptor (EGFR) as a target. We discuss the development and testing of LTT bispecific targeting EGFR and urokinase-type plasminogen activator receptor (Upar) as two attractive targets involved in tumor growth and in the regulation of the tumor microvasculature in solid tumors. In vitro and mouse xenograft studies have demonstrated that EGFR-targeted bispecific angiotoxin (eBAT) effective against human solid tumors. Studies have shown that eBAT dog is safe and effective against canine hemangiosarcoma, which are physiologically similar to human angiosarcoma.

Finding the right dose strategy and sequencing eBAT administration, in combination with other therapies, among the factors important for the future direction. Together, the data suggest that stem cells eBAT cancer targets, may have a role in inhibiting tumor blood vessels, human, and bispecific conformations that may have a role in reducing the toxicity of the oncologic comparative trials in dogs.
The urokinase plasminogen activator and its receptor (uPA / Upar) is a biomarker for metastasis, particularly in triple-negative breast cancer.

We set up an anti-mitotic N-alkylisatin (N-AI) -loaded liposomes functionalized with uPA / Upar targeting ligand, plasminogen activator inhibitor type 2 (PAI-2 / SerpinB2), and rated liposome uptake in vitro and in vivo. receptor dependent uptake of liposome-functionalized PAI-2 was significantly higher in the uPA / Upar overexpressing MDA-MB-231 breast cancer cells is relatively low Upar / Upar expressing MCF-7 breast cancer cells. Furthermore, N-AI cytotoxicity enhanced by receptor-dependent manner.

In vivo, PAI-2 N-AI liposomes have a plasma half-life of 5.82 h and showed increased accumulation at the primary tumor site in the MDA-MB-231 BALB / c-Fox1nu / Ausb mouse orthotopic xenograft model, relative to non-functionalized liposome , up to 6 hours post injection. These findings support the further development of the N-AI-loaded liposomes PAI-2-enabled for breast cancer uPA / Upar-positive, especially against triple-negative breast cancer, the prognosis is poor and treatment is limited.

Soluble urokinase plasminogen activator receptor as a prognostic biomarker for long-term acute coronary syndrome

Objective: The aim of our study was to analyze the long-term prognostic value soluble urokinase plasminogen activator receptor (Supar) in the setting of acute coronary syndromes (ACS) .Methods: We included 340 patients with ACS undergoing coronary angiography and plasma concentrations were measured Supar. Patients were classified into Supar low concentrations (<2.6 ng / mL) and high Supar concentration (≥2.6 ng / mL) and long-term events are evaluated.

Supar rated prognostic value beyond the clinical model that included age, GRACE score, estimated glomerular filtration rate, cardiac troponin-I peak and left ventricular ejection fraction <40% .Results: Higher concentrations Supar associated with an increased prevalence of cardiovascular risk factors.

Human Urokinase
7-03803	CHI Scientific	1mg	Ask for price

Human Urokinase
7-03804	CHI Scientific	5mg	Ask for price

Human Urokinase
RP-1463	Alpha Diagnostics	100 ug	EUR 164

Camptothecin (2 mg/ml)
1039-1	Biovision		EUR 142

MG 1
HY-U00110	MedChemExpress	5mg	EUR 601

Urokinase
30R-2710	Fitzgerald	100 ug	EUR 423
Description: Purified native Human Urokinase

Urokinase
4793-100	Biovision		EUR 321

Urokinase,
4793-1000	Biovision		EUR 1349

Urokinase, human recombinant
7696-10	Biovision		EUR 218

Urokinase, human recombinant
7696-50	Biovision		EUR 544

Urokinase, human recombinant
7696-500	Biovision		EUR 1893

Accuris 1 Hour Mammalian Genotyping Kit
PR1300-MG-400	BenchMark	1 PC	EUR 453.38

Accuris 1 Hour Mammalian Genotyping Kit
PR1300-MG-80	BenchMark	1 PC	EUR 154.32

Accuris 1 Hour Mammalian Genotyping Kit
PR1300-MG-S	BenchMark	1 PC	EUR 71.38

rRTF (1-mg)*
41055-2	Pel-Freez	1mg	EUR 841.48

Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody
11661-05011	AssayPro	150 ug	EUR 217

Synthetic Adjuvant Combo Pak-1 (contains 1 mg of Gardiquimod (#AV-8010), Imiquimod (#AV-8015) and 1 mg R848 (#AV-8020-1)
AV-8000-PK-1	Alpha Diagnostics	1 pk	EUR 347

Urokinase protein
30C-CP8107	Fitzgerald	50 ug	EUR 405
Description: Purified Recombinant Human Urokinase protein

Urokinase antibody
5793-100	Biovision		EUR 338

Urokinase antibody
5793-30T	Biovision		EUR 146

Urokinase Antibody
abx024172-200ul	Abbexa	200 ul	EUR 578

Urokinase Antibody
49439-100ul	SAB	100ul	EUR 333

Urokinase Antibody
49439-50ul	SAB	50ul	EUR 239

Custom Peptide Conjugation to KLH/BSA/Ovalbumin or agarose (mg-100 mg size, price based upon servicesa)
CONJ-1	Alpha Diagnostics	1	Ask for price

Pro-Urokinase, human recombinant
7695-10	Biovision		EUR 202

Pro-Urokinase, human recombinant
7695-50	Biovision		EUR 479

Pro-Urokinase, human recombinant
7695-500	Biovision		EUR 1675

Human Urokinase ELISA kit
E01U0010-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit
E01U0010-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase ELISA kit
E01U0010-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Urokinase (uPA) Antibody
11651-05011	AssayPro	150 ug	EUR 217

Human ?1-microglobulin,?1-MG ELISA Kit
201-12-1093	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Pyrene azide 1, 1 mg
A1530	lumiprobe	1 mg	EUR 108

Cyanine5.5 azide, 1 mg
A4030	lumiprobe	1 mg	EUR 108

Cyanine7.5 azide, 1 mg
A6030	lumiprobe	1 mg	EUR 108

Cyanine7.5 alkyne, 1 mg
A60B0	lumiprobe	1 mg	EUR 108

Cyanine5.5 alkyne, 1 mg
A70B0	lumiprobe	1 mg	EUR 108

Cyanine5.5 DBCO, 1 mg
A70F0	lumiprobe	1 mg	EUR 108

Cyanine5 alkyne, 1 mg
A30B0	lumiprobe	1 mg	EUR 108

Cyanine5 DBCO, 1 mg
A30F0	lumiprobe	1 mg	EUR 108

Cyanine7 azide, 1 mg
A5030	lumiprobe	1 mg	EUR 108

Cyanine7 alkyne, 1 mg
A50B0	lumiprobe	1 mg	EUR 108

Cyanine7 DBCO, 1 mg
A50F0	lumiprobe	1 mg	EUR 108

Perylene azide, 1 mg
A5530	lumiprobe	1 mg	EUR 108

Cyanine3.5 azide, 1 mg
A2030	lumiprobe	1 mg	EUR 108

Cyanine5 azide, 1 mg
A3030	lumiprobe	1 mg	EUR 108

PEP azide, 1 mg
A4530	lumiprobe	1 mg	EUR 108

Cyanine3 azide, 1 mg
A1030	lumiprobe	1 mg	EUR 108

Cyanine3 alkyne, 1 mg
A10B0	lumiprobe	1 mg	EUR 108

Cyanine3 DBCO, 1 mg
A10F0	lumiprobe	1 mg	EUR 108

Cyanine3 hydrazide, 1 mg
11070	lumiprobe	1 mg	EUR 108

Cyanine3 maleimide, 1 mg
11080	lumiprobe	1 mg	EUR 108

Cyanine3 amine, 1 mg
110C0	lumiprobe	1 mg	EUR 108

Cyanine5 hydrazide, 1 mg
13070	lumiprobe	1 mg	EUR 108

Cyanine5 maleimide, 1 mg
13080	lumiprobe	1 mg	EUR 108

Cyanine5 amine, 1 mg
130C0	lumiprobe	1 mg	EUR 108

Pyrene hydrazide, 1 mg
13570	lumiprobe	1 mg	EUR 108

Pyrene maleimide, 1 mg
13580	lumiprobe	1 mg	EUR 108

Cyanine7 hydrazide, 1 mg
15070	lumiprobe	1 mg	EUR 108

Cyanine7 maleimide, 1 mg
15080	lumiprobe	1 mg	EUR 108

Cyanine7 amine, 1 mg
150C0	lumiprobe	1 mg	EUR 108

Cyanine7.5 hydrazide, 1 mg
16070	lumiprobe	1 mg	EUR 108

Cyanine7.5 maleimide, 1 mg
16080	lumiprobe	1 mg	EUR 108

Cyanine7.5 amine, 1 mg
160C0	lumiprobe	1 mg	EUR 108

Cyanine5.5 hydrazide, 1 mg
17070	lumiprobe	1 mg	EUR 108

Cyanine5.5 maleimide, 1 mg
17080	lumiprobe	1 mg	EUR 108

Cyanine5.5 amine, 1 mg
170C0	lumiprobe	1 mg	EUR 108

Pepsin, 1 mg, lyophilized
6011	Chondrex	1 mg	EUR 63.05
Description: Pepsin

Human Anti-NKX3.1 IgG, 1 mg
314	AthenaES	1 mg	EUR 480

Human Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody (Biotin Conjugate)
11661-05021	AssayPro	150 ug	EUR 276

CF405S monoclonal mouse anti-biotin IgG, 2 mg/mL
20203-1	Biotium	50uL	EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF488A monoclonal mouse anti-biotin IgG, 2 mg/mL
20204-1	Biotium	50uL	EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF594 monoclonal mouse anti-biotin IgG, 2 mg/mL
20205-1	Biotium	50uL	EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF633 monoclonal mouse anti-biotin IgG, 2 mg/mL
20206-1	Biotium	50uL	EUR 149
Description: Minimum order quantity: 1 unit of 50uL

CF640R monoclonal mouse anti-biotin IgG, 2 mg/mL
20207-1	Biotium	50uL	EUR 149
Description: Minimum order quantity: 1 unit of 50uL

Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size)
20007-1-BL-1	Alpha Diagnostics	10 ml	Ask for price

CF488A Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20071-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF594 Rabbit anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20072-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF488A Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20074-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF594 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20075-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF633 Donkey anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20076-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF640R goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20081-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20097-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20132-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20154-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF555 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20230-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

CF647 goat anti-human IgG(H+L), highly cross-adsorbed, 2 mg/mL
20280-1	Biotium	50uL	EUR 137
Description: Minimum order quantity: 1 unit of 50uL

Mouse Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody
12171-05011	AssayPro	150 ug	EUR 217

Human urokinase,UK ELISA Kit
CN-04011H1	ChemNorm	96T	EUR 434

Human urokinase,UK ELISA Kit
CN-04011H2	ChemNorm	48T	EUR 284

Human urokinase(UK)ELISA Kit
GA-E0818HM-48T	GenAsia Biotech	48T	EUR 289

Human urokinase(UK)ELISA Kit
GA-E0818HM-96T	GenAsia Biotech	96T	EUR 466

Human urokinase,UK ELISA Kit
201-12-0802	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Recombinant Human Urokinase/PLAU Protein
RP00146LQ	Abclonal	5 μg	EUR 164

Human urokinase(UK)ELISA Kit
QY-E02059	Qayee Biotechnology	96T	EUR 361

Urokinase Sepharose Beads
7927-25	Biovision		EUR 1762

Urokinase Sepharose Beads
7927-5	Biovision		EUR 697

Anti-Urokinase (3B8)
YF-MA14762	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to Urokinase

Polyclonal Urokinase antibody
APR10695G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Urokinase . This antibody is tested and proven to work in the following applications:

Anti-Urokinase antibody
STJ16100595	St John's Laboratory	1 mL	EUR 419

Anti-Urokinase antibody
STJ16100610	St John's Laboratory	1 mL	EUR 419

Anti-Urokinase antibody
STJ16101190	St John's Laboratory	0.5 mg	EUR 381

Anti-Urokinase antibody
STJ16101191	St John's Laboratory	0.5 mg	EUR 381

Urokinase Conjugated Antibody
C49439	SAB	100ul	EUR 397

CF647 rabbit anti-goat IgG(H+L), 2 mg/mL
20049-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660C goat anti-mouse IgG(H+L), 2 mg/mL
20050-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660C goat anti-rabbit IgG(H+L), 2 mg/mL
20053-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660R goat anti-mouse IgG(H+L), 2 mg/mL
20054-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF660R goat anti-rabbit IgG(H+L), 2 mg/mL
20055-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF680 rabbit anti-goat IgG(H+L), 2 mg/mL
20068-1	Biotium	50uL	EUR 132
Description: Minimum order quantity: 1 unit of 50uL

CF750 goat anti-mouse IgG(H+L), 2 mg/mL
20070-1	Biotium	50uL	EUR 132
Description: Minimum order quantity: 1 unit of 50uL

CF750 goat anti-rabbit IgG(H+L), 2 mg/mL
20073-1	Biotium	50uL	EUR 132
Description: Minimum order quantity: 1 unit of 50uL

CF405S goat anti-mouse IgG(H+L), 2 mg/mL
20080-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF405S goat anti-rabbit IgG(H+L), 2 mg/mL
20082-1	Biotium	50ul	EUR 120
Description: Minimum order quantity: 1 unit of 50ul

CF640R goat anti-swine IgG(H+L), 2 mg/mL
20089-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF640R rabbit anti-goat IgG(H+L), 2 mg/mL
20090-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-swine IgG(H+L), 2 mg/mL
20091-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF568 goat anti-mouse IgG(H+L), 2 mg/mL
20100-1	Biotium	50ul	EUR 120
Description: Minimum order quantity: 1 unit of 50ul

CF568 goat anti-rabbit IgG(H+L), 2 mg/mL
20102-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF568 rabbit anti-goat IgG(H+L), 2 mg/mL
20107-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-mouse IgG(H+L), 2 mg/mL
20110-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-rabbit IgG(H+L), 2 mg/mL
20112-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-mouse IgG(H+L), 2 mg/mL
20120-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-rabbit IgG(H+L), 2 mg/mL
20122-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 rabbit anti-goat IgG(H+L), 2 mg/mL
20128-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF633 goat anti-swine IgG(H+L), 2 mg/mL
20138-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF350 goat anti-mouse IgG(H+L), 2 mg/mL
20140-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF350 goat anti-rabbit IgG(H+L), 2 mg/mL
20141-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF594 goat anti-swine IgG(H+L), 2 mg/mL
20160-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF405M goat anti-mouse IgG(H+L), 2 mg/mL
20180-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

CF405M goat anti-rabbit IgG(H+L), 2 mg/mL
20181-1	Biotium	50uL	EUR 120
Description: Minimum order quantity: 1 unit of 50uL

After multivariate adjustment, Supar ≥2.6 ng / mL were independently associated with an increased risk of all-cause mortality (HR 2.3; 95% CI 1.2 to 4.4; p = 0.017), major adverse cardiovascular events (MACE) ( HR 1.7; 95% CI 1.1 to 2.5; p = 0.020) and heart failure (HR 4.1; 95% CI 1.3 to 12.6; p = 0.015), but not with myocardial infarction , For long-term all-cause mortality significant increase of reclassification and discrimination Supar look after addition to the clinical model.