Introduction: Differentiation between sepsis and systemic inflammatory response syndrome (SIRS) remains a diagnostic challenge to physicians because they may have a similar clinical presentation. A rapid and accurate diagnostic tool that can distinguish between these two conditions will help in the proper therapeutic decision making. This prospective study was performed to evaluate the diagnostic and prognostic utility soluble urokinase-type plasminogen activator receptor (Supar) and procalcitonin (PCT) in patients with sepsis and SIRS.
Materials and Methods : Eighty-eight patients were enrolled, of which 29 are SIRS and sepsis 59 is a patient. Supar and PCT level was measured on the day of admission (day 1), day 3 and day 7.
Results: Levels Supar and PCT was significantly higher (p = 0.05 and p <0.001, respectively) in the sepsis group compared with SIRS group. Soluble urokinase-type plasminogen activator receptor is a better diagnostic tool in predicting sepsis more PCT [area under the curve (AUC) was 0.89 vs. 0.82] on day 1. The best cutoff for Supar was 5.58 pg / mL [ 96% sensitivity and 90% negative predictive value (NPV)] and the best cut-off for PCT was 1.96 ng / mL (sensitivity 93.1% and 80% NPV). However, the PCT has a better prognostic trend (p = 0.006) to identify nonsurvivors in sepsis group.
Conclusions: Our findings suggest that both Supar and PCT can be used as a potential test for distinguishing between SIRS and sepsis. Procalcitonin showed a significant prognostic trends to identify nonsurvivors. Soluble urokinase-type plasminogen activator receptor showed better diagnostic potential of PCT on day 1.
Clinical significance: Second Supar and PCT can be used as a surrogate biomarker to distinguish sepsis from SIRS. Procalcitonin showed a significant prognostic trends to identify nonsurvivors can help physicians to take clinical decisions that are relevant. Also, the use of biomarkers such as PCT and Supar can reduce the use of antibiotics in SIRS noninfective.
How to cite this article: Sharma A, Ray S, Mamidipalli R, Kakar A, Chugh P, Jain R, et al. A Comparative Study of the Diagnostic and Utility late prognosis Urokinase-type Plasminogen Activator Receptor and procalcitonin in patients with Sepsis and Systemic Inflammatory Response Syndrome.
A Comparative Study of the Diagnostic and Prognostic Utility of Soluble Urokinase-type Plasminogen Activator Receptor and Procalcitonin in Patients with Sepsis and Systemic Inflammation Response Syndrome
Late Urokinase Plasminogen Activator Receptor (Supar) concentrations were elevated in patients with Neuroendocrine Malignancies
Neuroendocrine neoplasia (NEN) comprise a heterogeneous tumors that are challenging to diagnose and, especially in cases of poorly differentiated (G3) Nen, is associated with a very limited survival. Novel biomarkers enabling early diagnosis and optimal selection of appropriate treatment options are needed to improve patient outcomes. More recently, changes in serum levels of soluble urokinase-type plasminogen activator receptor (Supar) is described in various types of cancer. However, Supar outstanding role as a biomarker in patients with unknown Nen.
In this study, we measured serum levels in a cohort Supar large and well-marked from 187 patients with NEN (neuroendocrine carcinoma (NEC) n = 30; neuroendocrine tumors (NET), n = 157) and 44 healthy controls. Supar concentration was significantly increased in patients compared with controls. crine carcinoma (NEC) n = 30; neuroendocrine tumors (NET), n = 157) and 44 healthy controls.
Supar concentration was significantly increased in patients compared with controls. However, the concentration of Supar independent of tumor-related factors such as proliferation activity by Ki-67, tumor grading, TNM (TNM classification of malignant tumor) stage, the expression of somatostatin receptors or clinical features such as functional or nonfunctional disease and the presence of tumor recurrence.
HIV Infection Enhancer (Medium) (1 ml)
H901-1
101Bio
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Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11
MASF-5A-Clone-10E11
Immunology Consultants Laboratory
1 mg
EUR 667
Description:
Anti-ASFV P72 Antibody | MASF-5A-Clone #10E11 | Immunology Consultants Laboratory
Host: Mouse
Format: Unconjugated AP
Product Type: Primary Antibody
Antibody Clonality: Monoclonal
Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5
MASF-5A-Clone-10G5
Immunology Consultants Laboratory
1 mg
EUR 667
Description:
Anti-ASFV P72 Antibody | MASF-5A-Clone #10G5 | Immunology Consultants Laboratory
Host: Mouse
Format: Unconjugated AP
Product Type: Primary Antibody
Antibody Clonality: Monoclonal
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Immunology Consultants Laboratory
1.0 mg
EUR 448
Description:
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#3B11 | Immunology Consultants Laboratory
Host: Mouse
Format: Unconjugated AP
Product Type: Primary Antibody
Antibody Clonality: Monoclonal
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Immunology Consultants Laboratory
1.0 mg
EUR 448
Description:
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Host: Mouse
Format: Unconjugated AP
Product Type: Primary Antibody
Antibody Clonality: Monoclonal
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2
MALV-30A-Clone-6C2
Immunology Consultants Laboratory
1.0 mg
EUR 448
Description:
Anti-Avian Leukosis Virus Antibody | MALV-30A-Clone#6C2 | Immunology Consultants Laboratory
Host: Mouse
Format: Unconjugated AP
Product Type: Primary Antibody
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Immunology Consultants Laboratory
1.0 mg
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Description:
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Host: Mouse
Format: Unconjugated AP
Product Type: Primary Antibody
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Camptothecin (2 mg/ml)
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Kanamycin solution (50mg/ml)
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Description: Minimum order quantity: 1 unit of 50uL
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Description: Minimum order quantity: 1 unit of 50uL
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Description: Anti-BOB-1/OBF-1 Rabbit Monoclonal Antibody, Clone#RM378 tested in WB, IHC, reactive to Human
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1/pk
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Description: Bioscience Mag Beads; Magnetic Dye
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AAVancedTM Concentration Reagent (100 ml aliquot)
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ScyTek Laboratories
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ScyTek Laboratories
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0.1 ml
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0.1 ml
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ScyTek Laboratories
0.1 ml
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ScyTek Laboratories
0.1 ml
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ExoQuick Plasma prep and Exosome precipitation kit (5 ml ExoQuick plus 500 ul Thrombin at 500U/mL)
EXOQ5TM-1
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75 reactions
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Steady-Luc Firefly HTS Assay Kit (12 ml)
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Description: Minimum order quantity: 1 unit of 1KIT
PEG-it Virus Precipitation Solution (250 mL aliquot)
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250 ml
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PEG-it Virus Precipitation Solution (100 mL aliquot)
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100 ml
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Water-soluble Cumate solution (300mg/ml, 10,000x), 500ul
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500 ul
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TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker); Clone 8G7G3/1 (Concentrate)
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ScyTek Laboratories
0.1 ml
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BosterBio
100ug
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Alpha Diagnostics
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p21WAF1 (Tumor Suppressor Protein); Clone WA-1 (HJ21) (Concentrate)
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ScyTek Laboratories
0.1 ml
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RA0100-C.1
ScyTek Laboratories
0.1 ml
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ScyTek Laboratories
0.1 ml
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ScyTek Laboratories
0.1 ml
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CD31 / PECAM-1 (Endothelial Cell Marker); Clone C31.3 (Concentrate)
RA0257-C.1
ScyTek Laboratories
0.1 ml
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CD31 / PECAM-1 (Endothelial Cell Marker); Clone 1A10 (Concentrate)
RA0260-C.1
ScyTek Laboratories
0.1 ml
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Mitochondria (Marker for Human Cells); Clone AE-1 (Concentrate)
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ScyTek Laboratories
0.1 ml
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Retinol Binding Protein-1 (RBP1); Clone RBP/872 (Concentrate)
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ScyTek Laboratories
0.1 ml
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Arginase 1 (Hepatocellular Carcinoma Marker); Clone ARG1/1125 (Concentrate)
RA0457-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Arginase 1 (Hepatocellular Carcinoma Marker); Clone ARG1/1126 (Concentrate)
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ScyTek Laboratories
0.1 ml
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AXYPREP MAG PCR NORMALIZER KIT- 1 ML - (SAMPLE SIZE)
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1/pk
EUR 87.6
Description: Bioscience Mag Beads; Magnetic PCR Normaliser
CD57 / B3GAT1 (Natural Killer Cell Marker); Clone HNK-1 & NK-1 (Concentrate)
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ScyTek Laboratories
0.1 ml
EUR 150
ExoQuick-CG cGMP-grade Exosome Isolation reagent (50 ml)
EXOCG50A-1
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50 ml
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CF543 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20326-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF543 Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
20327-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF555 goat anti-rabbit IgG(H+L), 2mg/mL
20033-1
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50uL
EUR 144
Description: Minimum order quantity: 1 unit of 50uL
CF647 goat anti-mouse IgG(H+L), 2mg/mL
20040-1
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50uL
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Description: Minimum order quantity: 1 unit of 50uL
CF647 goat anti-rabbit IgG(H+L), 2mg/mL
20043-1
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50uL
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Description: Minimum order quantity: 1 unit of 50uL
CF405S monoclonal mouse anti-biotin IgG, 2 mg/mL
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF488A monoclonal mouse anti-biotin IgG, 2 mg/mL
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF594 monoclonal mouse anti-biotin IgG, 2 mg/mL
20205-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF633 monoclonal mouse anti-biotin IgG, 2 mg/mL
20206-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF640R monoclonal mouse anti-biotin IgG, 2 mg/mL
20207-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF405M monoclonal mouse anti-fluorescein (FITC) IgG, 2mg/mL
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50uL
EUR 193.2
Description: Minimum order quantity: 1 unit of 50uL
CF350 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20255-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF488A Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20256-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF555 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20257-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF568 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20258-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF594 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20259-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF633 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20260-1
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF640R Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20261-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF647 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20262-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF680 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20263-1
Biotium
50uL
EUR 193.2
Description: Minimum order quantity: 1 unit of 50uL
CF770 Goat Anti-Mouse IgG2a (γ2a), 2mg/mL
20264-1
Biotium
50uL
EUR 193.2
Description: Minimum order quantity: 1 unit of 50uL
CF350 Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
20265-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF488A Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
20266-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF555 Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
20267-1
Biotium
50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF568 Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
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50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF594 Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
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Description: Minimum order quantity: 1 unit of 50uL
CF633 Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
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EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL
CF640R Goat Anti-Mouse IgG2b (γ2b), 2mg/mL
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Biotium
50uL
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Description: Minimum order quantity: 1 unit of 50uL
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Description: Minimum order quantity: 1 unit of 50uL
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EUR 193.2
Description: Minimum order quantity: 1 unit of 50uL
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Description: Minimum order quantity: 1 unit of 50uL
Anti-CD163 Rabbit Monoclonal Antibody, Clone#RM371
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BosterBio
100uL
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Description: Anti-CD163 Rabbit Monoclonal Antibody, Clone#RM371 tested in WB, IHC, reactive to Human
Anti-Paxillin Rabbit Monoclonal Antibody, Clone#RM256
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BosterBio
100uL
EUR 450
Description: Anti-Paxillin Rabbit Monoclonal Antibody, Clone#RM256 tested in WB, IHC, reactive to Human
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Anti-LC3B Rabbit Monoclonal Antibody, Clone#RM293
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BosterBio
100uL
EUR 498
Description: Anti-LC3B Rabbit Monoclonal Antibody, Clone#RM293 tested in WB, IHC, ICC, reactive to Human
Anti-CD21 Rabbit Monoclonal Antibody, Clone#RM372
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BosterBio
100uL
EUR 462
Description: Anti-CD21 Rabbit Monoclonal Antibody, Clone#RM372 tested in WB, IHC, reactive to Human
Anti-PLAP Rabbit Monoclonal Antibody, Clone#RM317
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BosterBio
100uL
EUR 462
Description: Anti-PLAP Rabbit Monoclonal Antibody, Clone#RM317 tested in WB, IHC, reactive to Human
Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275
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BosterBio
100uL
EUR 476.4
Description: Anti-JAM1 Rabbit Monoclonal Antibody, Clone#RM275 tested in WB, IHC, reactive to Human
Anti-SATB2 Rabbit Monoclonal Antibody, Clone#RM365
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BosterBio
100uL
EUR 462
Description: Anti-SATB2 Rabbit Monoclonal Antibody, Clone#RM365 tested in WB, IHC, reactive to Human
Anti-CD5 Rabbit Monoclonal Antibody, Clone#RM314
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BosterBio
100uL
EUR 476.4
Description: Anti-CD5 Rabbit Monoclonal Antibody, Clone#RM314 tested in WB, IHC, reactive to Human
Anti-PSMA Rabbit Monoclonal Antibody, Clone#RM327
M02846-1
BosterBio
100uL
EUR 462
Description: Anti-PSMA Rabbit Monoclonal Antibody, Clone#RM327 tested in WB, IHC, reactive to Human
Anti-mTOR Rabbit Monoclonal Antibody, Clone#RM274
M00003-1
BosterBio
100uL
EUR 476.4
Description: Anti-mTOR Rabbit Monoclonal Antibody, Clone#RM274 tested in WB, IHC, reactive to Human
(Mouse or Rat)
Anti-MYD88 Rabbit Monoclonal Antibody, Clone#RM306
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BosterBio
100uL
EUR 462
Description: Anti-MYD88 Rabbit Monoclonal Antibody, Clone#RM306 tested in WB, IHC, reactive to Human
Anti-Smad4 Rabbit Monoclonal Antibody, Clone#RM277
M00074-1
BosterBio
100uL
EUR 476.4
Description: Anti-Smad4 Rabbit Monoclonal Antibody, Clone#RM277 tested in WB, IHC, reactive to Human
(Mouse or Rat)
Anti-MSH2 Rabbit Monoclonal Antibody, Clone#RM375
M00140-1
BosterBio
100uL
EUR 462
Description: Anti-MSH2 Rabbit Monoclonal Antibody, Clone#RM375 tested in WB, IHC, reactive to Human
Anti-ALK Rabbit Monoclonal Antibody, Clone#RM361
M00301-1
BosterBio
100uL
EUR 462
Description: Anti-ALK Rabbit Monoclonal Antibody, Clone#RM361 tested in WB, IHC, reactive to Human
Anti-CD4 Rabbit Monoclonal Antibody, Clone#RM345
M00344-1
BosterBio
100uL
EUR 476.4
Description: Anti-CD4 Rabbit Monoclonal Antibody, Clone#RM345 tested in WB, IHC, reactive to Human
Anti-MSH6 Rabbit Monoclonal Antibody, Clone#RM376
M00553-1
BosterBio
100uL
EUR 462
Description: Anti-MSH6 Rabbit Monoclonal Antibody, Clone#RM376 tested in WB, IHC, reactive to Human
BrightGreen miRNA qPCR MasterMix-Low ROX
MasterMix-mL
ABM
4 x 1.25 ml for 500 reactions
EUR 181.2
Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #1)
CDTA12-M-1
Alpha Diagnostics
100 ug
EUR 578.4
Mouse Monoclonal anti-Clostridium difficile toxin B IgG (Clone #1)
CDTB12-M-1
Alpha Diagnostics
100 ug
EUR 578.4
Calponin-1 (Smooth Muscle Marker); Clone CNN1/832 & CALP (Concentrate)
RA0101-C.1
ScyTek Laboratories
0.1 ml
EUR 150
MART-1 / Melan-A / MLANA (Melanoma Marker); Clone A103 (Concentrate)
RA0114-C.1
ScyTek Laboratories
0.1 ml
EUR 150
MAGE-1 (Target for Cancer Immunotherapy); Clone MZ2E/838 (Concentrate)
RA0202-C.1
ScyTek Laboratories
0.1 ml
EUR 150
PDCD1 / PD1 / CD279 (Programmed Cell Death 1); Clone NAT105 (Concentrate)
RA0254-C.1
ScyTek Laboratories
0.1 ml
EUR 150
CD31 / PECAM-1 (Endothelial Cell Marker); Clone JC/70A (Concentrate)
RA0259-C.1
ScyTek Laboratories
0.1 ml
EUR 150
CD31 / PECAM-1 (Endothelial Cell Marker); Clone PECA1/848 (Concentrate)
RA0261-C.1
ScyTek Laboratories
0.1 ml
EUR 150
CD31 / PECAM-1 (Endothelial Cell Marker); Clone 158-2B3 (Concentrate)
RA0262-C.1
ScyTek Laboratories
0.1 ml
EUR 150
CD57 / B3GAT1 (Natural Killer Cell Marker); Clone NK-1 (Concentrate)
RA0356-C.1
ScyTek Laboratories
0.1 ml
EUR 150
HPV-16 (Human Papilloma Virus 16); Clone CAMVIR-1 (Concentrate)
RA0380-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Cytokeratin, Pan (Epithelial Marker); Clone AE-1 & AE-3 (Concentrate)
RA0382-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Myeloid Cell Marker (Macrophage / Granulocyte Marker); Clone BM-1 (Concentrate)
RA0400-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Melanoma Marker (MART-1 & gp100); Clone DT101, BC199, & HMB45 (Concentrate)
RA0413-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Fascin-1 (Reed-Sternberg Cell Marker); Clone FSCN1/417 (Concentrate)
RA0450-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker); Clone AACT/1451 (Concentrate)
RA0521-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Alpha-1-Antichymotrypsin (SERPINA3) (Histiocytoma Marker); Clone AACT/1452 (Concentrate)
RA0522-C.1
ScyTek Laboratories
0.1 ml
EUR 150
Modular In Situ-1 96 Well Crystallization Plate
ML-MIS-FP3D
MiTeGen
1 PLATE
EUR 392
Description: Modular In Situ-1 96 Well Crystallization Plate
AXYPREP MAG PCR CLEAN UP KIT- 1 ML - (SAMPLE SIZE)
MAG-PCR-CL-1
CORNING
1/pk
EUR 69.6
Description: Bioscience Mag Beads; Magnetic PCR Clean Up
Histone H3 Methylation Antibody Panel Pack I – Active Genes
C10000
EpiGentek
Histone H3 Methylation Antibody Panel Pack I – Repression Genes
C10001
EpiGentek
Histone H3 Methylation Antibody Panel Pack II – Active Genes
C10002
EpiGentek
Histone H3 Methylation Antibody Panel Pack II – Repression Genes
C10003
EpiGentek
Histone H3 Methylation Antibody Panel Pack III – Active Genes
C10004
EpiGentek
Histone H3K4 Methylation Antibody Panel Pack
C10005
EpiGentek
Histone H3K9 Methylation Antibody Panel Pack
C10006
EpiGentek
Histone H3K27 Methylation Antibody Panel Pack
C10007
EpiGentek
Histone H3K36 Methylation Antibody Panel Pack
C10008
EpiGentek
Histone H3K79 Methylation Antibody Panel Pack
C10009
EpiGentek
Histone H3 Acetylation Antibody Panel Pack I
C10010
EpiGentek
Histone H3 Acetylation Antibody Panel Pack II
C10011
EpiGentek
Histone H4K20 Methylation Antibody Panel Pack
C10012
EpiGentek
Histone H4 Acetylation Antibody Panel Pack
C10013
EpiGentek
Histone H3 Phosphorylation Antibody Panel Pack
C10014
EpiGentek
Histone H3R2 Methylation Antibody Panel Pack
C10015
EpiGentek
Histone H3R8 Methylation Antibody Panel Pack
C10016
EpiGentek
Histone H3R17 Methylation Antibody Panel Pack
C10017
EpiGentek
Histone H3R26 Methylation Antibody Panel Pack
C10018
EpiGentek
Histone H4R3 Methylation Antibody Panel Pack
C10019
EpiGentek
DNA Methylation Antibody Panel Pack I
C20000
EpiGentek
Interestingly, the concentration Supar on the same NET patients when compared with those measured in patients with NEC.
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