Introduction: Differentiation between sepsis and systemic inflammatory response syndrome (SIRS) remains a diagnostic challenge to physicians because they may have a similar clinical presentation. A rapid and accurate diagnostic tool that can distinguish between these two conditions will help in the proper therapeutic decision making. This prospective study was performed to evaluate the diagnostic and prognostic utility soluble urokinase-type plasminogen activator receptor (Supar) and procalcitonin (PCT) in patients with sepsis and SIRS.
Materials and Methods : Eighty-eight patients were enrolled, of which 29 are SIRS and sepsis 59 is a patient. Supar and PCT level was measured on the day of admission (day 1), day 3 and day 7.
Results: Levels Supar and PCT was significantly higher (p = 0.05 and p <0.001, respectively) in the sepsis group compared with SIRS group. Soluble urokinase-type plasminogen activator receptor is a better diagnostic tool in predicting sepsis more PCT [area under the curve (AUC) was 0.89 vs. 0.82] on day 1. The best cutoff for Supar was 5.58 pg / mL [ 96% sensitivity and 90% negative predictive value (NPV)] and the best cut-off for PCT was 1.96 ng / mL (sensitivity 93.1% and 80% NPV). However, the PCT has a better prognostic trend (p = 0.006) to identify nonsurvivors in sepsis group.
Conclusions: Our findings suggest that both Supar and PCT can be used as a potential test for distinguishing between SIRS and sepsis. Procalcitonin showed a significant prognostic trends to identify nonsurvivors. Soluble urokinase-type plasminogen activator receptor showed better diagnostic potential of PCT on day 1.
Clinical significance: Second Supar and PCT can be used as a surrogate biomarker to distinguish sepsis from SIRS. Procalcitonin showed a significant prognostic trends to identify nonsurvivors can help physicians to take clinical decisions that are relevant. Also, the use of biomarkers such as PCT and Supar can reduce the use of antibiotics in SIRS noninfective.
How to cite this article: Sharma A, Ray S, Mamidipalli R, Kakar A, Chugh P, Jain R, et al. A Comparative Study of the Diagnostic and Utility late prognosis Urokinase-type Plasminogen Activator Receptor and procalcitonin in patients with Sepsis and Systemic Inflammatory Response Syndrome.
A Comparative Study of the Diagnostic and Prognostic Utility of Soluble Urokinase-type Plasminogen Activator Receptor and Procalcitonin in Patients with Sepsis and Systemic Inflammation Response Syndrome
Late Urokinase Plasminogen Activator Receptor (Supar) concentrations were elevated in patients with Neuroendocrine Malignancies
Neuroendocrine neoplasia (NEN) comprise a heterogeneous tumors that are challenging to diagnose and, especially in cases of poorly differentiated (G3) Nen, is associated with a very limited survival. Novel biomarkers enabling early diagnosis and optimal selection of appropriate treatment options are needed to improve patient outcomes. More recently, changes in serum levels of soluble urokinase-type plasminogen activator receptor (Supar) is described in various types of cancer. However, Supar outstanding role as a biomarker in patients with unknown Nen.
In this study, we measured serum levels in a cohort Supar large and well-marked from 187 patients with NEN (neuroendocrine carcinoma (NEC) n = 30; neuroendocrine tumors (NET), n = 157) and 44 healthy controls. Supar concentration was significantly increased in patients compared with controls. crine carcinoma (NEC) n = 30; neuroendocrine tumors (NET), n = 157) and 44 healthy controls.
Supar concentration was significantly increased in patients compared with controls. However, the concentration of Supar independent of tumor-related factors such as proliferation activity by Ki-67, tumor grading, TNM (TNM classification of malignant tumor) stage, the expression of somatostatin receptors or clinical features such as functional or nonfunctional disease and the presence of tumor recurrence.
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CF647 rabbit anti-goat IgG(H+L), 2 mg/mL
20049-1
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EUR 120
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EUR 120
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EUR 120
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EUR 120
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CF633 goat anti-mouse IgG(H+L), 2 mg/mL
20120-1
Biotium
50uL
EUR 120
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CF633 goat anti-rabbit IgG(H+L), 2 mg/mL
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50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF633 rabbit anti-goat IgG(H+L), 2 mg/mL
20128-1
Biotium
50uL
EUR 120
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CF633 goat anti-swine IgG(H+L), 2 mg/mL
20138-1
Biotium
50uL
EUR 120
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CF350 goat anti-mouse IgG(H+L), 2 mg/mL
20140-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF350 goat anti-rabbit IgG(H+L), 2 mg/mL
20141-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF594 goat anti-swine IgG(H+L), 2 mg/mL
20160-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF405M goat anti-mouse IgG(H+L), 2 mg/mL
20180-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF405M goat anti-rabbit IgG(H+L), 2 mg/mL
20181-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
Biotin goat anti-mouse IgG(H+L), 2 mg/mL
20183-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
Biotin goat anti-rabbit IgG(H+L), 2 mg/mL
20185-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF640R goat anti-mouse IgG(H+L), 2 mg/mL
20197-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF640R goat anti-rabbit IgG(H+L), 2 mg/mL
20202-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF488A chicken anti-mouse IgG(H+L), 2 mg/mL
20208-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
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20209-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
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20210-1
Biotium
50uL
EUR 161
Description: Minimum order quantity: 1 unit of 50uL
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20221-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF633 chicken anti-mouse IgG(H+L), 2 mg/mL
20222-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF594 chicken anti-rabbit IgG(H+L), 2 mg/mL
20223-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF633 chicken anti-rabbit IgG(H+L), 2 mg/mL
20224-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF488A chicken anti-goat IgG(H+L), 2 mg/mL
20225-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF594 chicken anti-goat IgG(H+L), 2 mg/mL
20226-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF633 chicken anti-goat IgG(H+L), 2 mg/mL
20227-1
Biotium
50uL
EUR 125
Description: Minimum order quantity: 1 unit of 50uL
CF555 goat anti-swine IgG(H+L), 2 mg/mL
20236-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF647 goat anti-swine IgG(H+L), 2 mg/mL
20286-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF543 goat anti-mouse IgG(H+L), 2 mg/mL
20306-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF543 goat anti-rabbit IgG(H+L), 2 mg/mL
20309-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF543 rabbit anti-goat IgG(H+L), 2 mg/mL
20315-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF543 goat anti-swine IgG(H+L), 2 mg/mL
20324-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
NATtrol Respiratory Validation Panel (RVP) (Qualitative) (13 X 0.2 mL)
NATRVP-1
Zeptometrix
13 X 0.2 mL
EUR 688.56
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TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker); Clone 8G7G3/1 (Concentrate)
RA0310-C.1
ScyTek Laboratories
0.1 ml
EUR 125
Anti-Core Histone Macro-H2A.1 (H2AFY) Rabbit Monoclonal Antibody, Clone#RM248
M04635-1
BosterBio
100ug
EUR 473
Description: Anti-Core Histone Macro-H2A.1 (H2AFY) Rabbit Monoclonal Antibody, Clone#RM248 tested in WB, ELISA, Multiplex, ICC, reactive to All Vertebrates
CF555 goat anti-guinea pig IgG(H+L), 2 mg/mL
20036-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF647 goat anti-guinea pig IgG(H+L), 2 mg/mL
20041-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF488A Rabbit anti-chicken IgY (IgG) (H+L), 2 mg/mL
20079-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF640R goat anti-guinea pig IgG(H+L), 2 mg/mL
20085-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF568 goat anti-guinea pig IgG(H+L), 2 mg/mL
20108-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF633 goat anti-guinea pig IgG(H+L), 2 mg/mL
20129-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF594 rabbit anti-chicken IgY ( IgG) (H+L), 2 mg/mL
20164-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF633 rabbit anti-chicken IgY (IgG) (H+L), 2 mg/mL
20165-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF350 goat anti-guinea pig IgG(H+L), 2 mg/mL
20198-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF680 rabbit anti-guinea pig IgG(H+L), 2 mg/mL
20243-1
Biotium
50uL
EUR 132
Description: Minimum order quantity: 1 unit of 50uL
CF770 rabbit anti-guinea pig IgG(H+L), 2 mg/mL
20244-1
Biotium
50uL
EUR 132
Description: Minimum order quantity: 1 unit of 50uL
CF543 rabbit anti-chicken IgY (IgG) (H+L), 2 mg/mL
20312-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF543 goat anti-guinea pig IgG(H+L), 2 mg/mL
20317-1
Biotium
50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
Thrombin Plasma prep for Exosome precipitation (500 ul at 500U/mL)
TMEXO-1
SBI
100 reactions
EUR 583
Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #1)
PEG13-M-1
Alpha Diagnostics
100 ug
EUR 482
p21WAF1 (Tumor Suppressor Protein); Clone WA-1 (HJ21) (Concentrate)
RA0074-C.1
ScyTek Laboratories
0.1 ml
EUR 125
Calponin-1 (Smooth Muscle Marker); Clone CNN1/832 (Concentrate)
RA0100-C.1
ScyTek Laboratories
0.1 ml
EUR 125
MAGE-1 (Target for Cancer Immunotherapy); Clone MA454 (Concentrate)
RA0201-C.1
ScyTek Laboratories
0.1 ml
EUR 125
CD31 / PECAM-1 (Endothelial Cell Marker); Clone C31.7 (Concentrate)
RA0256-C.1
ScyTek Laboratories
0.1 ml
EUR 125
CD31 / PECAM-1 (Endothelial Cell Marker); Clone C31.3 (Concentrate)
RA0257-C.1
ScyTek Laboratories
0.1 ml
EUR 125
CD31 / PECAM-1 (Endothelial Cell Marker); Clone 1A10 (Concentrate)
RA0260-C.1
ScyTek Laboratories
0.1 ml
EUR 125
Interestingly, the concentration Supar on the same NET patients when compared with those measured in patients with NEC.
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