Objective: Cervical cancer metastasis results in a poor prognosis and increased mortality, which is not free from the accumulation of inflammatory reaction by prostaglandin E2 (PGE2). As a special G-protein coupled receptors of PGE2, EP3 is shown as a negative prognosticator cervical malignancy. Now, we aim to investigate the pathological mechanism of EP3 in modulating carcinogenesis of cervical cancer.
Methods: Bioinformatics analysis was used to identify PAI-1 and Upar correlation with EP3 expression, as well as the prognosis of patients with cervical cancer. In vitro analyzes were conducted to investigate the role of EP3 against cervical cancer proliferation and migration.
Results: In vitro studies indicate that sulprostone (EP3 agonist) increases the proliferation and migration of cervical cancer cells, whereas silencing of EP3 inhibits their proliferation and migration. Furthermore, EP3 knockdown increased the expression of plasminogen activator inhibitor type 1 (PAI-1), urokinase-type plasminogen activator receptor (Upar), and phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1 / 2), but decreased p53 expression. bioinformatics analysis showed that both PAI-1 and Upar correlated with EP3 expression, as well as the prognosis of patients with cervical cancer. Survival analysis further indicated that excessive Upar (IRSā„2) correlated with overall survival rates lower than patients with advanced cervical cancer (FIGO III-IV).
Conclusion: These results indicate that the EP3 signaling pathway may facilitate migration of cervical cancer cells through modulation of the expression of Upar. Therefore, EP3 and Upar could represent a new therapeutic target in the treatment of cervical cancer in stage wins.
Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR)
Intrapleural urokinase directly under medical thoracoscopy for the diagnosis of TB pleurisy.
medical thoracoscopy, also called “local anesthetic thoracoscopy” and “pleuroscopy,” is a single-port endoscopic minimally invasive technique that provides direct visualization of the pleural surface and channel to perform diagnostic and therapeutic procedures. However, this technique does not help when there are substantial fibrous adhesions. We report the first case of intrapleural urokinase directly under medical thoracoscopy for the diagnosis of malignant pleural mesothelioma with pleural effusion severe multiloculated in 2019. This is the second report on the efficacy of intrapleural urokinase directly under medical thoracoscopy for the diagnosis of pleural effusion multiloculated. Urokinase-induced intrapleural fibrinolysis, which removed the fibrous septa, consequently increasing the field of view under the endoscope within only 10 minutes. fibrinolytic effect appears very quickly.
This technique is available for tuberculous pleurisy with pleural effusion multiloculated severe.
Given the accumulating evidence on the negative predictive value of soluble urokinase plasminogen activator receptor (Supar), a group of experts from the fields of intensive care medicine, emergency medicine, internal medicine and infectious diseases at the position statement framing Supar role in screening patients admitted to the emergency department. The statement was framed taking into account the existing publications and research experience of our own.
Description: A competitive ELISA for quantitative measurement of Canine Urokinase plasminogen activator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Urokinase plasminogen activator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Active caspase 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Urokinase type Plasminogen Activator Receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Urokinase type Plasminogen Activator Receptor ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Urokinase type Plasminogen Activator Receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Urokinase type Plasminogen Activator Receptor ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Urokinase type Plasminogen Activator Receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog soluble urokinase plasminogen activator receptor ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine soluble urokinase plasminogen activator receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog soluble urokinase plasminogen activator receptor ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine soluble urokinase plasminogen activator receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog soluble urokinase plasminogen activator receptor ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine soluble urokinase plasminogen activator receptor in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A sandwich ELISA for quantitative measurement of Canine Cuticular Active Peptide Factor,CAPF in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Cuticular Active Peptide Factor,CAPF ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Cuticular Active Peptide Factor,CAPF in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Cuticular Active Peptide Factor,CAPF ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Cuticular Active Peptide Factor,CAPF in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Mouse Amminoterminal Fragment Urokinase [ATF-Urokinase (uPA)] Antibody
Description: A competitive ELISA for quantitative measurement of Canine Active Gastric inhibitory polypeptide (1 42) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active Gastric inhibitory polypeptide (1 42) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Active Gastric inhibitory polypeptide (1 42) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active Gastric inhibitory polypeptide (1 42) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Active Gastric inhibitory polypeptide (1 42) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Urokinase . This antibody is tested and proven to work in the following applications:
Description: Human AKT Serine/Threonine Kinase 1 (AKT1), also known as Protein Kinase B Alpha (PKBα), and RAC, GenBank Accession No. NM_001014432, a.a. 1-480(full length) with N-terminal His-tag, was expressed in Sf9 insect cells via a baculovirus expression system. MW=60 kDa. The purified AKT1 is activated in vitro using PDK1 enzyme.
Dog Active breakpoint cluster region related protein(ABR) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Active breakpoint cluster region related protein(ABR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active breakpoint cluster region related protein(ABR) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Active breakpoint cluster region related protein(ABR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active breakpoint cluster region related protein(ABR) ELISA kit
Description: A sandwich ELISA for quantitative measurement of Canine Active breakpoint cluster region related protein(ABR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active Glucagon Like Peptide 1(7 36) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Active Glucagon Like Peptide 1(7 36) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active Glucagon Like Peptide 1(7 36) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Active Glucagon Like Peptide 1(7 36) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Dog Active Glucagon Like Peptide 1(7 36) ELISA kit
Description: A competitive ELISA for quantitative measurement of Canine Active Glucagon Like Peptide 1(7 36) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Urokinase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: Recombinant Human Erythropoietin expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells
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The main contents of this statement is that Supar is a non-specific marker associated with high negative predictive value for an unfavorable outcome; levels <4 ng / ml indicates that it is safe to discharge patients, while levels> 6 ng / ml is a worrying sign for the risk of an unfavorable outcome. However, the level of Supar should always be interpreted in the light of the patient’s history.
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